caa a22 4500 477055974 CHVBK 20180405111346.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/s002280050206 doi (NATIONALLICENCE)springer-10.1007/s002280050206 Bioavailability of estradiol from a new matrix and a conventional reservoir-type transdermal therapeutic system [Elektronische Daten] [P. Müller, L. Botta, F. Ezzet] Objective: Bioavailability of estradiol delivered from a newly developed matrix-type transdermal therapeutic system (MTTS) was compared with that of the conventional reservoir-type system (RTTS). Both formulations have a nominal delivery rate of 50 μg per day of 17β-estradiol (E2). Plasma concentrations of E2 and estrone (E1) were determined at steady state during a 96-h application of each formulation to 34 postmenopausal volunteers, using a two-stage randomized two-period crossover design. Results: The MTTS proved to be equivalent to the RTTS with respect to the extent of E2 absorption. Due to differences in patch design and composition, the rate of absorption was different between the two systems, with less fluctuating E2 plasma levels during application of the matrix system. Local tolerability and adhesion of MTTS appeared to be better than those of the reservoir system. Springer-Verlag Berlin Heidelberg, 1996 Key words Hormone replacement therapy nationallicence estradiol nationallicence pharmacokinetics nationallicence bioequivalence nationallicence postmenopausal volunteers nationallicence Müller P. Human Pharmacology, K-1372.2.72, Ciba-Geigy Limited, CH-4002 Basel, Switzerland, CH aut Botta L. Pharma Division of Ciba-Geigy Limited, Research and Development Departments, CH-4002 Basel, Switzerland, CH aut Ezzet F. Pharma Division of Ciba-Geigy Limited, Research and Development Departments, CH-4002 Basel, Switzerland, CH aut https://doi.org/10.1007/s002280050206 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050206 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Müller P. Human Pharmacology, K-1372.2.72, Ciba-Geigy Limited, CH-4002 Basel, Switzerland, CH aut NATIONALLICENCE 700 1- Botta L. Pharma Division of Ciba-Geigy Limited, Research and Development Departments, CH-4002 Basel, Switzerland, CH aut NATIONALLICENCE 700 1- Ezzet F. Pharma Division of Ciba-Geigy Limited, Research and Development Departments, CH-4002 Basel, Switzerland, CH aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer