caa a22 4500 477056016 CHVBK 20180405111346.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/s002280050195 doi (NATIONALLICENCE)springer-10.1007/s002280050195 Calcium antagonist treatment and cardiovascular responses to a cold pressor test at high altitude [Elektronische Daten] [E. Hankø, M. Rostrup] Objective: We assessed the effects of the calcium antagonist felodipine on blood pressure, heart rate, oxygen saturation and cardiovascular responses to a cold pressor test at an altitude of 5200 m. Sixteen healthy climbers participated. A double-blind, placebo-controlled, randomized, crossover design was used. Placebo or felodipine were taken for 2 days and the treatment was changed after 3 days washout. Results: During felodipine treatment there were no significant changes in blood pressure (125/89 vs 127/86 mmHg), heart rate (82 vs 81 beats ⋅ min−1) or oxygen saturation (86% vs 86%). Moreover, there were no changes in the cardiovascular responses to the cold pressor test. Conclusion: Felodipine is well tolerated at high altitude. It does not induce hypotension in normotensive men and does not affect cardiovascular reactivity to cold stress. Springer-Verlag Berlin Heidelberg, 1996 Key words Calcium antagonists nationallicence Felodipine nationallicence Hypertension nationallicence cold pressor test nationallicence high altitude nationallicence Hankø E. Research Forum and Medical Department, Ullevål Hospital, University of Oslo, N-0407, Oslo, Norway, NO aut Rostrup M. Research Forum and Medical Department, Ullevål Hospital, University of Oslo, N-0407, Oslo, Norway, NO aut https://doi.org/10.1007/s002280050195 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050195 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hankø E. Research Forum and Medical Department, Ullevål Hospital, University of Oslo, N-0407, Oslo, Norway, NO aut NATIONALLICENCE 700 1- Rostrup M. Research Forum and Medical Department, Ullevål Hospital, University of Oslo, N-0407, Oslo, Norway, NO aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer