caa a22 4500 477056059 CHVBK 20180405111346.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/s002280050209 doi (NATIONALLICENCE)springer-10.1007/s002280050209 Lack of a pharmacokinetic interaction between moexipril and hydrochlorothiazide [Elektronische Daten] [V. Hutt, K. Michaelis, R. Verbesselt, P. J. De Schepper, P. Salomon, R. Bonn, W. Cawello, J. C. Angehrn] Objective: To investigate the potential for pharmacokinetic interactions between moexipril, a new converting enzyme inhibitor, and hydrochlorothiazide after single dose administration. Methods: 12 healthy male volunteers were studied by an open, randomised, three-way cross-over design, in which single doses of moexipril, hydrochlorothiazide and the two drugs together were administered. Blood and urine were collected up to 48 hours for measurement of the concentrations of moexipril and its metabolite moexiprilat. In addition, the urine samples were analysed for hydrochlorothiazide. Results: For the area under the plasma concentration-time curve calculated from time 0 to a concentration greater than zero, AUC(0-t), the study showed a mean value of moexipril 437 ng ⋅ ml−1⋅ h−1 following administration of moexipril alone and 416 ng ⋅ ml−1⋅ h−1 following moexipril concomitantly with hydrochloro- thiazide. The corresponding values for the metabolite moexiprilat were 203 and 215 ng ⋅ ml−1⋅ h−1, respectively. The cmax of moexipril and the metabolite (data of the metabolite in parenthesis) were 245.4 (70.8) ng ⋅ ml−1 after administration of moexipril alone and 241.0 (69.2) ng ⋅ ml−1 after coadministration of hydrochlorothiazide. The mean total renal excretion (TUE) of hydrochlorothiazide was 15.2 mg when administered alone and 15.1 mg when given together with moexipril. The corresponding mean TUE-values for moexiprilat were 334 (1200) and 453 (1460) μg. Conclusion: The coadministration of moexipril with hydrochlorothiazide had no demonstrable effect on the measured pharmacokinetic parameters of moexipril, its active metabolite moexiprilat or hydrochlorothiazide. Springer-Verlag Berlin Heidelberg, 1996 Key words Moexipril nationallicence Hydrochlorothiazide nationallicence pharmacokinetics nationallicence drug interaction nationallicence Hutt V. LAB Gesellschaft für Pharmakologische Untersuchungen mbH and Co, Neu-Ulm, Germany, DE aut Michaelis K. LAB Gesellschaft für Pharmakologische Untersuchungen mbH and Co, Neu-Ulm, Germany, DE aut Verbesselt R. Department of Pharmacology, Schools of Medicine and Pharmacy, University of Leuven, Belgium, BE aut Schepper P. J. De Department of Pharmacology, Schools of Medicine and Pharmacy, University of Leuven, Belgium, BE aut Salomon P. Clinical Pharmacology Institute, Sir Patrick Dun's Hospital, Dublin 2, Ireland, IE aut Bonn R. Schwarz Pharma AG, Monheim am Rhein, Germany, DE aut Cawello W. Schwarz Pharma AG, Monheim am Rhein, Germany, DE aut Angehrn J. C. Corning Besselaar, Zürich, Switerland, XX aut https://doi.org/10.1007/s002280050209 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050209 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hutt V. LAB Gesellschaft für Pharmakologische Untersuchungen mbH and Co, Neu-Ulm, Germany, DE aut NATIONALLICENCE 700 1- Michaelis K. LAB Gesellschaft für Pharmakologische Untersuchungen mbH and Co, Neu-Ulm, Germany, DE aut NATIONALLICENCE 700 1- Verbesselt R. Department of Pharmacology, Schools of Medicine and Pharmacy, University of Leuven, Belgium, BE aut NATIONALLICENCE 700 1- Schepper P. J. De Department of Pharmacology, Schools of Medicine and Pharmacy, University of Leuven, Belgium, BE aut NATIONALLICENCE 700 1- Salomon P. Clinical Pharmacology Institute, Sir Patrick Dun's Hospital, Dublin 2, Ireland, IE aut NATIONALLICENCE 700 1- Bonn R. Schwarz Pharma AG, Monheim am Rhein, Germany, DE aut NATIONALLICENCE 700 1- Cawello W. Schwarz Pharma AG, Monheim am Rhein, Germany, DE aut NATIONALLICENCE 700 1- Angehrn J. C. Corning Besselaar, Zürich, Switerland, XX aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer