caa a22 4500 477056091 CHVBK 20180405111346.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/s002280050204 doi (NATIONALLICENCE)springer-10.1007/s002280050204 Transdermally administered nicotine accumulates in gastric juice [Elektronische Daten] [G. Lindell, E. Lunell, H. Graffner] Methods: Transdermal nicotine patches (Nicorette® 15 mg ⋅ 16 h-1) were administered to 7 healthy volunteers. Nicotine concentrations in gastric juice were monitored for 8 h via a naso-gastric tube and so was nicotine in saliva and plasma. Results: Nicotine accumulated in gastric juice, the average concentration being 60.6-times higher than in plasma. In saliva, too, the concentration was higher than in plasma, the average ratio being 10.5. These results strongly suggested ion-trapping of nicotine base in the acidic gastric juice and possibly also in the acinar cells, followed by active secretion. It is hypothesised that accumulation in saliva occurs via a similar mechanism. Pretreatment with omeprazole did not increase the pH to a sufficiently high degree to test the hypothesis that the accumulation of nicotine in gastric juice was pH dependent. Conclusions: Transdermal administration of nicotine produced a high intragastric concentration. The clinical consequence of this effect of long-term nicotine replacement therapy during smoking cessation is unclear. Springer-Verlag Berlin Heidelberg, 1996 Key words Gastric juice nationallicence nicotine nationallicence ion-trapping nationallicence peptic ulcer disease nationallicence smoking cessation nationallicence transdermal patch nationallicence saliva nationallicence Lindell G. Department of Surgery, University Hospital Lund, Sweden, SE aut Lunell E. Pharmacia AB Lund and Department of Clinical Pharmacology, University Hospital Lund, Karl XI gatan 4, S-22220 Lund Sweden, SE aut Graffner H. Department of Surgery, Helsingborg County Hospital, Sweden, SE aut https://doi.org/10.1007/s002280050204 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050204 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lindell G. Department of Surgery, University Hospital Lund, Sweden, SE aut NATIONALLICENCE 700 1- Lunell E. Pharmacia AB Lund and Department of Clinical Pharmacology, University Hospital Lund, Karl XI gatan 4, S-22220 Lund Sweden, SE aut NATIONALLICENCE 700 1- Graffner H. Department of Surgery, Helsingborg County Hospital, Sweden, SE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer