caa a22 4500 47705627X CHVBK 20180405111347.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/s002280050191 doi (NATIONALLICENCE)springer-10.1007/s002280050191 Colchicine enhances intestinal permeability in patients with familial Mediterranean fever [Elektronische Daten] [A. Fradkin, J. Yahav, A. Diver-Haber, D. Zemer, A. Jonas] Abstract  : Objective: Colchicine therapy is complicated by frequent gastrointestinal adverse effects. Methods: We compared intestinal permeability in 21 patients with familial Mediterranean fever on long-standing colchine therapy (mean 5.8 years) and significant gastrointestinal complaints and 12 untreated patients and 14 healthy volunteers. The double probe (lactulose/mannitol) permeability test was performed using a hyperosmolar test solution (1580 mosmol) and the differential urinary recovery ratios were calculated. Results: Familial Mediterranean fever patients on colchicine therapy had significantly higher lactulose/mannitol urinary excretion ratios (0.073) compared to untreated patients (0.035) and to healthy controls (0.021). Untreated familial Mediterranean fever patients had significantly greater urinary lactulose/mannitol recovery ratios than controls (P < 0.02). No correlation was found between the degree of enhanced permeability and the length of exposure to the drug or the severity of clinical symptoms. Conclusion: Intestinal permeability was significantly enhanced in patients with familial Mediterranean fever treated with colchicine. Springer-Verlag Berlin Heidelberg, 1996 Key words  Colchicine nationallicence intestinal permeability nationallicence familial Mediterranean fever nationallicence Fradkin A. Pediatric Gastrointestinal Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel, IL aut Yahav J. Pediatric Gastrointestinal Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel, IL aut Diver-Haber A. Pediatric Gastrointestinal Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel, IL aut Zemer D. Heller Institute for Medical Research The Chaim Sheba Medical Center, Tel Hashomer, Israel, IL aut Jonas A. Pediatric Gastrointestinal Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel, IL aut https://doi.org/10.1007/s002280050191 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050191 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fradkin A. Pediatric Gastrointestinal Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel, IL aut NATIONALLICENCE 700 1- Yahav J. Pediatric Gastrointestinal Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel, IL aut NATIONALLICENCE 700 1- Diver-Haber A. Pediatric Gastrointestinal Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel, IL aut NATIONALLICENCE 700 1- Zemer D. Heller Institute for Medical Research The Chaim Sheba Medical Center, Tel Hashomer, Israel, IL aut NATIONALLICENCE 700 1- Jonas A. Pediatric Gastrointestinal Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel, IL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer