caa a22 4500 477056342 CHVBK 20180405111347.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/s002280050184 doi (NATIONALLICENCE)springer-10.1007/s002280050184 The differentiation of propafenone from other class Ic agents, focusing on the effect on ventricular response rate attributable to its beta-blocking action [Elektronische Daten] [T. S. Faber, A. J. Camm] Propafenone, encainide and flecainide have been categorized as class Ic antiarrhythmic drugs, since they produce similar clinical electrophysiological effects. However, propafenone has also modes of action that differ substantially from pure class Ic activity. The most distinctive electrophysiological difference from other class Ic antiarrhythmic drugs stems from its structural similarity with other beta-adrenoceptor antagonists. The potency of the β-adrenoceptor blocking property of propafenone has been estimated to range from 1/20 to 1/50 that of propranolol on a molar basis. Because the plasma concentrations of propafenone during long-term treatment may be up to 50 or more times that of propranolol, the β-adrenoceptor blocking effect may be clinically relevant. However, although the β-adrenoceptor blocking effects are readily demonstrable in vitro, clinical data are more inconsistent, because the β-adrenoceptor blocking action has been reported as being undetectable to significant. During atrial fibrillation, with or without accessory pathways, propafenone exerts effective and prompt control of the ventricular rate in patients who fail to convert to sinus rhythm. However, compared with other class Ic antiarrhythmic drugs, propafenone has not been proved generally better in controlling the ventricular rate. Springer-Verlag Berlin Heidelberg, 1996 Key words Propafenone nationallicence encainide nationallicence flecainide nationallicence β-adrenoceptor blockade nationallicence ventricular response nationallicence Ic agents nationallicence antiarrhythmic agents nationallicence Faber T. S. Department of Cardiological Sciences, St. George's Hospital Medical School, Cranmer Terrace, London SW 17 ORE, UK, GB aut Camm A. J. Department of Cardiological Sciences, St. George's Hospital Medical School, Cranmer Terrace, London SW 17 ORE, UK, GB aut https://doi.org/10.1007/s002280050184 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050184 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Faber T. S. Department of Cardiological Sciences, St. George's Hospital Medical School, Cranmer Terrace, London SW 17 ORE, UK, GB aut NATIONALLICENCE 700 1- Camm A. J. Department of Cardiological Sciences, St. George's Hospital Medical School, Cranmer Terrace, London SW 17 ORE, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer