caa a22 4500 477056423 CHVBK 20180405111347.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/s002280050159 doi (NATIONALLICENCE)springer-10.1007/s002280050159 Lack of effect of the serotonin4 receptor agonist zacopride on ACTH secretion in normal men [Elektronische Daten] [H. Lefebvre, V. Contesse, C. Delarue, J. M. Kuhn, H. Vaudry, L. M. Wolf] Objective: In the present study, we investigated the effect of zacopride on corticotropin (ACTH) and cortisol secretion in healthy volunteers. Male subjects received a single oral dose of placebo, 10 μg zacopride or 400 μg zacopride. Plasma ACTH, cortisol and aldosterone concentrations were measured before and during the 3 h following the administration of the drug. Results: For none of the doses did zacopride cause any modification of plasma ACTH or cortisol levels. In contrast, administration of 400 μg zacopride induced a significant increase in plasma aldosterone levels. Conclusion: Our results indicate that in humans serotonin-evoked stimulation of ACTH secretion is not mediated through serotonin4 (5-HT4) receptors. Together with previous findings, these data indicate that the stimulatory effect of 5-HT4 receptor agonists on aldosterone secretion in man can be ascribed solely to a direct action on glomerulosa cells. Springer-Verlag Berlin Heidelberg, 1996 Key words Serotonin nationallicence Zacopride nationallicence ACTH secretion nationallicence cortisol secretion nationallicence benzamide derivatives nationallicence 5-HT4 receptor nationallicence Lefebvre H. Clinique Médicale et Endocrinologique, Hôpital de Boisguillaume, CHU de Rouen, F-76031 Rouen Cedex, France, FR aut Contesse V. European Institute for Peptide Research, IFRMP No 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA CNRS, University of Rouen, Mont-Saint-Aignan, France, FR aut Delarue C. European Institute for Peptide Research, IFRMP No 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA CNRS, University of Rouen, Mont-Saint-Aignan, France, FR aut Kuhn J. M. European Institute for Peptide Research, IFRMP No 23, Group for Hormone Research, CHU of Rouen, Rouen, France, FR aut Vaudry H. European Institute for Peptide Research, IFRMP No 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA CNRS, University of Rouen, Mont-Saint-Aignan, France, FR aut Wolf L. M. European Institute for Peptide Research, IFRMP No 23, Group for Hormone Research, CHU of Rouen, Rouen, France, FR aut https://doi.org/10.1007/s002280050159 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050159 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lefebvre H. Clinique Médicale et Endocrinologique, Hôpital de Boisguillaume, CHU de Rouen, F-76031 Rouen Cedex, France, FR aut NATIONALLICENCE 700 1- Contesse V. European Institute for Peptide Research, IFRMP No 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA CNRS, University of Rouen, Mont-Saint-Aignan, France, FR aut NATIONALLICENCE 700 1- Delarue C. European Institute for Peptide Research, IFRMP No 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA CNRS, University of Rouen, Mont-Saint-Aignan, France, FR aut NATIONALLICENCE 700 1- Kuhn J. M. European Institute for Peptide Research, IFRMP No 23, Group for Hormone Research, CHU of Rouen, Rouen, France, FR aut NATIONALLICENCE 700 1- Vaudry H. European Institute for Peptide Research, IFRMP No 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA CNRS, University of Rouen, Mont-Saint-Aignan, France, FR aut NATIONALLICENCE 700 1- Wolf L. M. European Institute for Peptide Research, IFRMP No 23, Group for Hormone Research, CHU of Rouen, Rouen, France, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer