caa a22 4500 477056520 CHVBK 20180405111347.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/s002280050158 doi (NATIONALLICENCE)springer-10.1007/s002280050158 Oral therapy with combined enalapril, prazosin and hydrochlorothiazide in the acute treatment of severe hypertension in Nigerians [Elektronische Daten] [A. A. Ajayi, M. A. Afolabi, M. O. Balogun, A. Q. Adigun, O. E. Ajayi, A. O. Akintomide] Objective: The efficacy, safety, tolerability and speed of onset of the hypotensive action of the combination of oral enalapril (10 mg) prazosin (1 mg) and hydrochlorothiazide (50 mg) has been assessed in 12 Nigerians with severe hypertension (Diastolic BP ≥115 mmHg). Patients: The ages of the patients ranged from 30-60 years, and the serum creatinine from 52-732 μmol⋅l−1. The initial blood pressure was 200/130 mmHg. Results: The combination significantly reduced systolic and diastolic blood pressure respectively. The hypotensive action appeared within 0.5 h and led to a fall in BP to 175/120 mmHg, and the peak action occurred at 4 h, when the BP was 138/99 mmHg, and it persisted upto 24 h (160/101 mmHg). Despite the significant fall in blood pressure, no reflex tachycardia was observed. Transient dizziness was seen in 2 patients, but otherwise all claimed improvement in clinical status and a clearer sensorium. Conclusion: The combination may be a useful oral treatment for the rapid control of severe hypertension in Blacks. Springer-Verlag Berlin Heidelberg, 1996 Key words Hypertension nationallicence Enalapril nationallicence Prazosin nationallicence Thiazide nationallicence Nigerians nationallicence drug combination nationallicence Ajayi A. A. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut Afolabi M. A. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut Balogun M. O. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut Adigun A. Q. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut Ajayi O. E. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut Akintomide A. O. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut https://doi.org/10.1007/s002280050158 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050158 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ajayi A. A. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut NATIONALLICENCE 700 1- Afolabi M. A. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut NATIONALLICENCE 700 1- Balogun M. O. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut NATIONALLICENCE 700 1- Adigun A. Q. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut NATIONALLICENCE 700 1- Ajayi O. E. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut NATIONALLICENCE 700 1- Akintomide A. O. College of Health Sciences, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, NG aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer