caa a22 4500 477056547 CHVBK 20180405111347.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/s002280050155 doi (NATIONALLICENCE)springer-10.1007/s002280050155 Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney in an Italian population [Elektronische Daten] [M. A. Ferroni, G. Marchi, E. Sansone, P. Romeo, P. C. Giulianotti, A. Pietrabissa, F. Mosca, G.-M. Pacifici] Objective. The polymorphism of erythrocyte thiopurine methyltransferase (TPMT) is genetically regulated as an autosomal codominant trait, and so should be congenital. Results. We tested this hypothesis by measuring TPMT activity in erythrocyte preparations from adults and newborns and observed polymorphic distribution of TPMT activity in the adult and newborn erythrocytes. The activity of TPMT was higher in red cells from the newborns than adults. The frequency distribution of TPMT activity was also investigated in the liver and kidney. In the kidney, TPMT activity fell into two subgroups, whereas in the liver the distribution pattern was more complex. The activity of TPMT in erythrocytes and liver from the same subject was correlated, but the values of only half the cases fell within the 95% confidence limits, suggesting that the control of hepatic and/or erythrocyte TPMT is multifactorial. Springer-Verlag Berlin Heidelberg, 1996 Key words 6-Mercaptopurine nationallicence Thiopurine methyltransferase nationallicence Polymorphism nationallicence erythrocytes nationallicence liver nationallicence kidney nationallicence newborns nationallicence adults nationallicence Ferroni M. A. Department of Biomedicine, Medical School, Via Roma 55, I-56126 Pisa, XX aut Marchi G. Department of Biomedicine, Medical School, Via Roma 55, I-56126 Pisa, XX aut Sansone E. Division of Gynaecology and Obstetrics, Hospital of Pisa, Via Roma 67, I-56126 Pisa, Italy, IT aut Romeo P. Division of Gynaecology and Obstetrics, Hospital of Pisa, Via Roma 67, I-56126 Pisa, Italy, IT aut Giulianotti P. C. Department of Surgical Pathology, Cisanello Hospital, I-56124 Cisanello, Pisa, University of Pisa, XX aut Pietrabissa A. Department of Surgical Pathology, Cisanello Hospital, I-56124 Cisanello, Pisa, University of Pisa, XX aut Mosca F. Department of Surgical Pathology, Cisanello Hospital, I-56124 Cisanello, Pisa, University of Pisa, XX aut Pacifici G.-M Department of Biomedicine, Medical School, Via Roma 55, I-56126 Pisa, XX aut https://doi.org/10.1007/s002280050155 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050155 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ferroni M. A. Department of Biomedicine, Medical School, Via Roma 55, I-56126 Pisa, XX aut NATIONALLICENCE 700 1- Marchi G. Department of Biomedicine, Medical School, Via Roma 55, I-56126 Pisa, XX aut NATIONALLICENCE 700 1- Sansone E. Division of Gynaecology and Obstetrics, Hospital of Pisa, Via Roma 67, I-56126 Pisa, Italy, IT aut NATIONALLICENCE 700 1- Romeo P. Division of Gynaecology and Obstetrics, Hospital of Pisa, Via Roma 67, I-56126 Pisa, Italy, IT aut NATIONALLICENCE 700 1- Giulianotti P. C. Department of Surgical Pathology, Cisanello Hospital, I-56124 Cisanello, Pisa, University of Pisa, XX aut NATIONALLICENCE 700 1- Pietrabissa A. Department of Surgical Pathology, Cisanello Hospital, I-56124 Cisanello, Pisa, University of Pisa, XX aut NATIONALLICENCE 700 1- Mosca F. Department of Surgical Pathology, Cisanello Hospital, I-56124 Cisanello, Pisa, University of Pisa, XX aut NATIONALLICENCE 700 1- Pacifici G.-M Department of Biomedicine, Medical School, Via Roma 55, I-56126 Pisa, XX aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer