caa a22 4500 47705658X CHVBK 20180405111347.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/s002280050157 doi (NATIONALLICENCE)springer-10.1007/s002280050157 Effect of nifedipine on superior mesenteric artery impedance in humans [Elektronische Daten] [D. Voet, S. Mareels, D. Duprez, M. De Buyzere, M. Afschrift, D. L. Clement] Objective: In a randomized, double-blind placebo-controlled study the acute effect of sublingual nifedipine (10 mg) on the superior mesenteric artery pulsatility index (PI) was studied over 60 min in 12 healthy subjects (Age 43 y). Methods: PI was considered as a parameter of vascular resistance and was calculated as the peak-to-peak amplitude of the waveform divided by the mean amplitude. PI measurements were performed with the subject resting and fasting and were made 5, 10, 15, 30, 45 and 60 min for 1 hour after nifedipine (10 mg) or placebo. Arterial blood pressure and heart rate were measured at the same times. Results: Placebo administration failed to change arterial blood pressure, heart rate or PI. 5 min after 10 mg sublingual nifedipine, PI had significantly decreased from 5.0 to 3.8, with a nonsignificant decrease in arterial blood pressure and an increase in heart rate. By 15 min after nifedipine administration PI had further decreased to 3.1, and there was a concomitant significant decrease in mean arterial blood pressure and increase in heart rate. Sixty minutes after drug intake PI and arterial blood pressure were still below baseline not significant but the heart rate remained significantly increased. Conclusion: Our data indicate that in healthy subjects sublingual administration of nifedipine had a vasodilator effect (decrease in PI) on the superior mesenteric vascular bed. Springer-Verlag Berlin Heidelberg, 1996 Key words Nifedipine nationallicence Blood pressure nationallicence calcium antagonist nationallicence pulsatility index nationallicence superior mesenteric artery nationallicence vasodilatation nationallicence Voet D. Department of Echography, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut Mareels S. Department of Echography, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut Duprez D. Department of Cardiology-Angiology, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut Buyzere M. De Department of Cardiology-Angiology, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut Afschrift M. Department of Echography, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut Clement D. L. Department of Cardiology-Angiology, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut https://doi.org/10.1007/s002280050157 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050157 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Voet D. Department of Echography, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut NATIONALLICENCE 700 1- Mareels S. Department of Echography, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut NATIONALLICENCE 700 1- Duprez D. Department of Cardiology-Angiology, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut NATIONALLICENCE 700 1- Buyzere M. De Department of Cardiology-Angiology, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut NATIONALLICENCE 700 1- Afschrift M. Department of Echography, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut NATIONALLICENCE 700 1- Clement D. L. Department of Cardiology-Angiology, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium, BE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer