caa a22 4500 477056636 CHVBK 20180405111347.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/s002280050162 doi (NATIONALLICENCE)springer-10.1007/s002280050162 Non invasive in vivo study of the maturation of CYP IIIA in neonates and infants [Elektronische Daten] [F. Vauzelle-Kervroedan, E. Rey, A. Pariente-Khayat, T. Bienvenu, J. Badoual, G. Olive, G. Pons] Objective: Cytochrome P450 III (CYP III) has previously been demonstrated in vitro in fetal liver. Methods: A study was performed in 7 premature, 13 term neonates and 30 infants to assess whether or not maturation had any influence on CYP IIIA activity in children from birth to 1 year of age. A simple non invasive procedure was used (6 βOHF/FF concentration ratio in a morning spot urine sample). Results: The 6 βOHF/FF ratio was 7.2, 7.9 and 5.0 in premature and term neonates and infants, respectively. CYP IIIA activity is present at birth, with a 6 βOHF/FF ratio comparable to adults. Its activity seemed lower in infants. This might be due to the decrease in CYP IIIA7 activity during maturation after birth, which might be more rapid than the increase in CYP IIIA3/4 activity. Springer-Verlag Berlin Heidelberg, 1996 Key words Cytochrome P450 IIIA nationallicence Maturation nationallicence Neonates nationallicence drug metabolism nationallicence 6 βOHF/FF ratio nationallicence infants nationallicence CYP IIIA7 nationallicence CYP IIIA3/4 nationallicence Vauzelle-Kervroedan F. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut Rey E. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut Pariente-Khayat A. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut Bienvenu T. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut Badoual J. Service de Pédiatrie Générale, Hópital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cédex 14, France, VC aut Olive G. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut Pons G. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut https://doi.org/10.1007/s002280050162 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050162 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vauzelle-Kervroedan F. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut NATIONALLICENCE 700 1- Rey E. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut NATIONALLICENCE 700 1- Pariente-Khayat A. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut NATIONALLICENCE 700 1- Bienvenu T. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut NATIONALLICENCE 700 1- Badoual J. Service de Pédiatrie Générale, Hópital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cédex 14, France, VC aut NATIONALLICENCE 700 1- Olive G. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut NATIONALLICENCE 700 1- Pons G. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, VC aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer