caa a22 4500 477056679 CHVBK 20180405111347.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/s002280050167 doi (NATIONALLICENCE)springer-10.1007/s002280050167 Effect of ranitidine on renal clearance of lomefloxacin [Elektronische Daten] [T. Sudoh, A. Fujimura, K. Harada, K. Sunaga, M. Ohmori, K. Sakamoto] Objective: To examine the effect of ranitidine on the renal clearance of lomefloxacin. Setting: Department of Clinical Pharmacology, Jichi Medical School. Methods: Lomefloxacin 200 mg and ranitidine 300 mg or its placebo were given orally in a randomised, double-blind, crossover design. Blood and urine samples were obtained during a 24-h period after dosing. Results: The area under the plasma concentration-time curve and the elimination half-life of lomefloxacin were significantly increased following coadministration with ranitidine. These effects were caused by significant decreases in total (7.8%) and renal (22%) clearance of lomefloxacin. In contrast, creatinine clearance and urinary excretion of electrolytes were not influenced by ranitidine. Conclusion: As lomefloxacin and ranitidine are excreted in urine by renal tubular secretion, the present results suggest that the renal tubular secretion of lomefloxacin is diminished by ranitidine. As the reduction in lomefloxacin clearance is only marginal, it is probable that the drug interaction observed in this study is not of clinical significance. Springer-Verlag Berlin Heidelberg, 1996 Key words Lomefloxacin nationallicence Ranitidine nationallicence renal clearance nationallicence drug interaction nationallicence Sudoh T. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut Fujimura A. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut Harada K. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut Sunaga K. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut Ohmori M. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut Sakamoto K. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut https://doi.org/10.1007/s002280050167 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050167 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sudoh T. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut NATIONALLICENCE 700 1- Fujimura A. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut NATIONALLICENCE 700 1- Harada K. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut NATIONALLICENCE 700 1- Sunaga K. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut NATIONALLICENCE 700 1- Ohmori M. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut NATIONALLICENCE 700 1- Sakamoto K. Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-04, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer