caa a22 4500 477056822 CHVBK 20180405111348.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/s002280050178 doi (NATIONALLICENCE)springer-10.1007/s002280050178 Single oral doses of amisulpride do not enhance the effects of alcohol on the performance and memory of healthy subjects [Elektronische Daten] [M. J. Mattila, A. Patat, T. Seppälä, H. Kalska, M.-L. Jalava, J. Vanakoski, C. Lavanant] Objectives: Amisulpride is a benzamide antipsychotic that binds selectively to dopamine D2- and D3-receptors, preferentially in limbic and hippocampal structures. Since other substituted benzamides have a limited or negligible interaction with alcohol on human performance, amisulpride was studied for this potential. Methods: In a randomised double-blind crossover study, 18 young, non-smoking men took single oral doses of placebo and amisulpride 50 mg and 200 mg, without and with ethanol (0.8 g ⋅kg−1) taken 30 min later. Objective performance tests and self-ratings were done at baseline and 1.5, 3.5 and 6.5 h after drug intake. Memory (immediate and delayed recall) was tested 2 h after dosing. Breath ethanol and the plasma concentrations of amisulpride and prolactin were measured. Three-way ANOVA + Newman-Keul tests were used for statistical analyses; interactions were confirmed by factorial contrast ANOVA. Results: Mean blood ethanol was 0.94, 0.62 and 0.26 g ⋅l−1 at the three test times. It produced significant impairment in all performance tests (symbol digit substitution, simulated driving, body sway, flicker fusion, tapping, nystagmus), reduced both immediate and delayed recall in memory tests, and caused subjective clumsiness, muzziness and mental slowness, mainly between 1.5 to 4.5 h after dosing. Amisulpride, 50 and 200 mg elevated plasma prolactin but had minimal or no effect on performance, attention and memory. The decreases in immediate free recall after the 50 mg dose and in delayed free recall after the 200 mg dose were slight. Amisulpride neither modified blood ethanol concentrations nor enhanced the detrimental effect of ethanol on skilled and cognitive performance; it slightly antagonised ethanol in the digit copying test. Ethanol did not modify the effect of amisulpride on plasma prolactin, and the plasma concentrations of amisulpride were little changed by ethanol. Conclusions: Amisulpride in single oral doses of 50 and 200 mg did not interact significantly with the effects of high, moderate or low concentrations of ethanol on human skilled and cognitive performance. The drugs did interact pharmacokinetically. Springer-Verlag Berlin Heidelberg, 1996 Key words Amisulpride nationallicence ethanol vector nationallicence performance nationallicence memory nationallicence cognitive function nationallicence interaction nationallicence pharmacokinetics nationallicence Mattila M. J. Department of Biomedicine Pharmacology and Toxicology, University of Helsinki, P.O. Box 8, Fin-00014 Helsinki, Finland, FI aut Patat A. Synthelabo Recherche, Bagneux, France, FR aut Seppälä T. The National Public Health Institute, Helsinki, Finland, FI aut Kalska H. Department of Applied Psychology, University of Helsinki, Helsinki, Finland, FI aut Jalava M.-L Department of Biomedicine Pharmacology and Toxicology, University of Helsinki, P.O. Box 8, Fin-00014 Helsinki, Finland, FI aut Vanakoski J. Department of Biomedicine Pharmacology and Toxicology, University of Helsinki, P.O. Box 8, Fin-00014 Helsinki, Finland, FI aut Lavanant C. Synthelabo Recherche, Bagneux, France, FR aut https://doi.org/10.1007/s002280050178 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050178 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mattila M. J. Department of Biomedicine Pharmacology and Toxicology, University of Helsinki, P.O. Box 8, Fin-00014 Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Patat A. Synthelabo Recherche, Bagneux, France, FR aut NATIONALLICENCE 700 1- Seppälä T. The National Public Health Institute, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Kalska H. Department of Applied Psychology, University of Helsinki, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Jalava M.-L Department of Biomedicine Pharmacology and Toxicology, University of Helsinki, P.O. Box 8, Fin-00014 Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Vanakoski J. Department of Biomedicine Pharmacology and Toxicology, University of Helsinki, P.O. Box 8, Fin-00014 Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Lavanant C. Synthelabo Recherche, Bagneux, France, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer