caa a22 4500 477056881 CHVBK 20180405111348.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/s002280050174 doi (NATIONALLICENCE)springer-10.1007/s002280050174 Effect of octreotide on blood glucose and counterregulatory hormones in insulin-dependent diabetic patients: the role of dose and route of administration [Elektronische Daten] [M. Lunetta, M. Di Mauro, R. Le Moli, F. Nicoletti] Objective: The role of the dose and route of administration of octreotide in addition to insulin on daily blood glucose, growth hormone, glucagon, cortisol and adrenaline profiles in 7 insulin-dependent diabetic patients have been studied. Octreotide was administered either as multiple subcutaneous injections (50 μg three times daily, total dose 150 μg) or by continuous subcutaneous infusion of lower 62.5 μg 24/h and 112.5 μg 24/h. Results: Blood glucose and growth hormone concentrations were lowered by octreotide in a similar manner regardless of the route of administration and dose. Glucagon concentrations at 12 and 16 h were reduced by all octreotide doses, but fasting at 20, 24 and 04 h concentrations were lowered only by 113 μg given by continuous infusion. Cortisol and adrenaline concentrations were not modified. Conclusions: Thus, low doses of octreotide administered by continuous infusion in addition to standard insulin treatment displayed the same hypoglycaemic effect as larger doses given by multiple injections without causing adverse-effects or hypoglycaemic episodes. Springer-Verlag Berlin Heidelberg, 1996 Key words Glycaemia nationallicence Diabetes (IDDM) nationallicence Octreotide nationallicence glucagon nationallicence growth hormone nationallicence Lunetta M. Department of Internal Medicine, Endocrinology and Metabolism, University of Catania, Catania, Italy, IT aut Mauro M. Di Department of Internal Medicine, Endocrinology and Metabolism, University of Catania, Catania, Italy, IT aut Moli R. Le Department of Internal Medicine, Endocrinology and Metabolism, University of Catania, Catania, Italy, IT aut Nicoletti F. Department of Internal Medicine, Endocrinology and Metabolism, University of Catania, Catania, Italy, IT aut https://doi.org/10.1007/s002280050174 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050174 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lunetta M. Department of Internal Medicine, Endocrinology and Metabolism, University of Catania, Catania, Italy, IT aut NATIONALLICENCE 700 1- Mauro M. Di Department of Internal Medicine, Endocrinology and Metabolism, University of Catania, Catania, Italy, IT aut NATIONALLICENCE 700 1- Moli R. Le Department of Internal Medicine, Endocrinology and Metabolism, University of Catania, Catania, Italy, IT aut NATIONALLICENCE 700 1- Nicoletti F. Department of Internal Medicine, Endocrinology and Metabolism, University of Catania, Catania, Italy, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer