caa a22 4500 47705689X CHVBK 20180405111348.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/s002280050145 doi (NATIONALLICENCE)springer-10.1007/s002280050145 Effects of carvedilol and atenolol on arterial pulse curves (plethysmography) and finger temperature after hand cooling [Elektronische Daten] [T. O. Klemsdal, H. H. Mundal, K. Gjesdal] Objective: In a double-blind, parallell study, the effects of 25 mg carvedilol and 50 mg atenolol on peripheral finger circulation and arterial pulse curve configuration were compared. Methods: Healthy volunteers (n = 17) were examined at baseline and for 15 min after 60 s of hand cooling in ice-water. Finger temperature and digital plethysmography were recorded each minute from the cooled and the control hands. Measurements were also made before and 2 h after drug administration. Results: Blood pressure declined from 120/86 to 108/74 mm Hg after atenolol (n = 9), and from 122/88 to 108/73 mm Hg after carvedilol (n = 8). In both groups, baseline finger temperature increased slightly after drug, and a more rapid rise in finger temperature was observed after cooling. There was no group difference in the drug effect on finger temperature, except in the first few minutes after cooling, when temperature recovery was greater after carvedilol. Carvedilol reduced the vasoconstrictor response to local cooling (digital plethysmography), compared both to the value before drug and after atenolol. At rest, carvedilol changed the pulse curves (control hand) towards vasodilatation and high compliance, expressed as a mean change in the relative height of the dicrotic notch of −10.3% versus 0.0% after atenolol. Conclusion: Future studies should clarify whether the vasoactive profile of carvedilol may translate into reduced occurrence of cold hands and feet amongst patients treated for hypertension. Springer-Verlag Berlin Heidelberg, 1996 Key words Carvedilol nationallicence Atenolol nationallicence finger temperature nationallicence finger plethysmography nationallicence haemodynamic effects nationallicence Klemsdal T. O. Ullevål University Hospital, Department of Cardiology, Ullevål University Hospital, N-0407 Oslo, Norway, NO aut Mundal H. H. Ullevål University Hospital, Department of Cardiology, Ullevål University Hospital, N-0407 Oslo, Norway, NO aut Gjesdal K. Department of Clinical Physiology, N-0407 Oslo, Norway, NO aut https://doi.org/10.1007/s002280050145 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050145 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Klemsdal T. O. Ullevål University Hospital, Department of Cardiology, Ullevål University Hospital, N-0407 Oslo, Norway, NO aut NATIONALLICENCE 700 1- Mundal H. H. Ullevål University Hospital, Department of Cardiology, Ullevål University Hospital, N-0407 Oslo, Norway, NO aut NATIONALLICENCE 700 1- Gjesdal K. Department of Clinical Physiology, N-0407 Oslo, Norway, NO aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer