caa a22 4500 477056946 CHVBK 20180405111348.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/s002280050141 doi (NATIONALLICENCE)springer-10.1007/s002280050141 Effect of clonidine and yohimbine on sleep in healthy men: a double-blind, randomized, controlled trial [Elektronische Daten] [A. Gentili, M. F. Godschalk, D. Gheorghiu, K. Nelson, D. A. Julius, T. Mulligan] Objective: To study the acute effect of clonidine, an α2-adrenoceptor agonist, and yohimbine, an α2-adrenoceptor antagonist, on nocturnal sleep in healthy men. Setting: McGuire Veteran Affairs Medical Center, Richmond, Virginia, USA. Subjects: Eight healthy male volunteers. Methods: Each subject slept in the sleep laboratory for 2 consecutive nights on three separate sessions, at 3-week intervals. On the 2nd night of each session, the subjects received yohimbine (5.4 mg), clonidine (0.1 mg), or placebo in a double-blind, randomized, placebo-controlled, crossover design. Results: There were no apparent effects of yohimbine. In contrast, clonidine completely suppressed rapid eye movement (REM) sleep in one subject and reduced REM sleep in the remaining seven subjects. Conclusion: Our study confirms that clonidine markedly decreases REM, even at a low single dose, and supports the hypothesis of the important role of α2-receptors in controlling REM sleep. Springer-Verlag Berlin Heidelberg, 1996 Key words REM sleep nationallicence Clonidine nationallicence Yohimbine nationallicence α2-adrenoceptors nationallicence man nationallicence Gentili A. Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Geriatrics and Extended Care (111T), 1201 Broad Rock Boulevard, Richmond, VA 23249, USA, US aut Godschalk M. F. Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Geriatrics and Extended Care (111T), 1201 Broad Rock Boulevard, Richmond, VA 23249, USA, US aut Gheorghiu D. Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Geriatrics and Extended Care (111T), 1201 Broad Rock Boulevard, Richmond, VA 23249, USA, US aut Nelson K. Psychiatry Service, Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA, US aut Julius D. A. Psychiatry Service, Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA, US aut Mulligan T. Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Geriatrics and Extended Care (111T), 1201 Broad Rock Boulevard, Richmond, VA 23249, USA, US aut https://doi.org/10.1007/s002280050141 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050141 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gentili A. Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Geriatrics and Extended Care (111T), 1201 Broad Rock Boulevard, Richmond, VA 23249, USA, US aut NATIONALLICENCE 700 1- Godschalk M. F. Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Geriatrics and Extended Care (111T), 1201 Broad Rock Boulevard, Richmond, VA 23249, USA, US aut NATIONALLICENCE 700 1- Gheorghiu D. Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Geriatrics and Extended Care (111T), 1201 Broad Rock Boulevard, Richmond, VA 23249, USA, US aut NATIONALLICENCE 700 1- Nelson K. Psychiatry Service, Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA, US aut NATIONALLICENCE 700 1- Julius D. A. Psychiatry Service, Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Richmond, VA, USA, US aut NATIONALLICENCE 700 1- Mulligan T. Medical College of Virginia and Hunter Holmes McGuire VA Medical Center, Geriatrics and Extended Care (111T), 1201 Broad Rock Boulevard, Richmond, VA 23249, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer