caa a22 4500 477056954 CHVBK 20180405111348.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/s002280050147 doi (NATIONALLICENCE)springer-10.1007/s002280050147 Effect of stiripentol on carbamazepine plasma concentration and metabolism in epileptic children [Elektronische Daten] [A. Tran, F. Vauzelle-Kervroedan, E. Rey, G. Pons, Ph d'Athis, C. Chiron, O. Dulac, F. Renard, G. Olive] Objective: To study the relationship between the plasma concentration of stiripentol (STP), a new antiepileptic drug, and its inhibitory effect on the formation of carbamazepine epoxide (CBZE) in epileptic children treated with carbamazepine (CBZ) either alone or in combination with another antiepileptic drug. Methods: Minimum plasma concentration of antiepileptic drugs was measured before initiation of STP therapy (day 0) and on days 28 (STP 60 mg⋅kg−1⋅day−1) and 84 (STP 90 mg⋅kg−1⋅day−1) by HPLC. Results: The CBZE/CBZ plasma concentration ratio decreased exponentially with increasing minimum plasma STP concentration (r = 0.80). The asymptote of the curve allowed the calculation of the minimum plasma STP concentration required to obtain the maximum inhibitory effect, i.e. 6.7 mg⋅l−1. Conclusion: The inhibitory effect of STP on CBZ metabolism expressed as the CBZE/CBZ plasma concentration ratio is dependent on STP plasma concentration, with a maximum effect at an average of 7 mg⋅l−1. The present data suggest that in order to evaluate the anticonvulsant efficacy of STP as add-on therapy, the minimum plasma STP concentration should be maintained above 7 mg⋅l−1 and the dosage of CBZ should simultaneously be decreased in steps by more than 50% to minimize the change in CBZ plasma concentration. Springer-Verlag Berlin Heidelberg, 1996 Key words Stiripentol nationallicence Carbamazepine nationallicence Epilepsia nationallicence drug metabolism nationallicence antiepileptic drugs nationallicence children nationallicence Tran A. Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut Vauzelle-Kervroedan F. Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut Rey E. Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut Pons G. Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut d'Athis Ph Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut Chiron C. Neuropediatrie Hôpital Saint-Vincent de Paul, Université René Descartes, Paris, France, VC aut Dulac O. Neuropediatrie Hôpital Saint-Vincent de Paul, Université René Descartes, Paris, France, VC aut Renard F. Laboratoire Biocodex, F-60200 Compiègne, France, FR aut Olive G. Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut https://doi.org/10.1007/s002280050147 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050147 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tran A. Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut NATIONALLICENCE 700 1- Vauzelle-Kervroedan F. Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut NATIONALLICENCE 700 1- Rey E. Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut NATIONALLICENCE 700 1- Pons G. Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut NATIONALLICENCE 700 1- d'Athis Ph Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut NATIONALLICENCE 700 1- Chiron C. Neuropediatrie Hôpital Saint-Vincent de Paul, Université René Descartes, Paris, France, VC aut NATIONALLICENCE 700 1- Dulac O. Neuropediatrie Hôpital Saint-Vincent de Paul, Université René Descartes, Paris, France, VC aut NATIONALLICENCE 700 1- Renard F. Laboratoire Biocodex, F-60200 Compiègne, France, FR aut NATIONALLICENCE 700 1- Olive G. Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes, Paris V, 82 Avenue Denfert Rochereau, F-75014 Paris, France, VC aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer