caa a22 4500 477057039 CHVBK 20180405111349.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/s002280050143 doi (NATIONALLICENCE)springer-10.1007/s002280050143 Oculo-bulbar myasthenia gravis induced by cytokine treatment of a patient with metastasized renal cell carcinoma [Elektronische Daten] [D. Rohde, U. Sliwka, K. Schweizer, G. Jakse] Objective: The occurrence of autoimmune diseases or deterioration of pre-existing disorders has recently been described after cytokine treatment. The present report gives evidence for acquired myasthenia gravis induced by externally administered interferon-α and interleukin-2 in a patient with metastasized renal cell carcinoma. Electromyographic investigations did not reveal generalised myasthenia gravis. However, a highly elevated titre of antibodies against the human acetylcholine receptor and a significant improvement in clinical symptoms during therapy with anticholinesterase drugs, combined with a decremental response in electronystagmography, indicated an intermittent mainly oculo-bulbar form of myasthenia gravis. Springer-Verlag Berlin Heidelberg, 1996 Key words Myasthenia gravis nationallicence Cytokine treatment nationallicence renal cell carcinoma nationallicence interferon-α nationallicence interleukin-2 nationallicence vaccination nationallicence toxicity nationallicence Rohde D. Department of Urology, Technical University of Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany, DE aut Sliwka U. Department of Neurology, Technical University of Aachen, Aachen, Germany, DE aut Schweizer K. Department of Immunology, Technical University of Aachen, Aachen, Germany, DE aut Jakse G. Department of Urology, Technical University of Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany, DE aut https://doi.org/10.1007/s002280050143 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050143 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rohde D. Department of Urology, Technical University of Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany, DE aut NATIONALLICENCE 700 1- Sliwka U. Department of Neurology, Technical University of Aachen, Aachen, Germany, DE aut NATIONALLICENCE 700 1- Schweizer K. Department of Immunology, Technical University of Aachen, Aachen, Germany, DE aut NATIONALLICENCE 700 1- Jakse G. Department of Urology, Technical University of Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer