caa a22 4500 47705708X CHVBK 20180405111349.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/s002280050096 doi (NATIONALLICENCE)springer-10.1007/s002280050096 Effect of food on the bioavailability of oxybutynin from a controlled release tablet [Elektronische Daten] [E. Lukkari, P. Castrèn-Kortekangas, A. Juhakoski, E. Löyttyniemi, K. Aranko, P. J. Neuvonen] Objective: The effect of food on the bioavailability of oxybutynin was assessed in a randomised cross-over study in 23 healthy volunteers. A single oral 10 mg dose of a controlled release oxybutynin tablet was administered after a high fat breakfast and to fasting subjects. The AUC, Cmax, tmax, t1/2 and MRT of oxybutynin and its active metabolite N-desethyloxybutynin were determined. Results: Breakfast did not change the AUC of oxybutynin but increased the AUC of N-desethyloxybutynin by about 20% . The Cmax of oxybutynin and N-desethyl oxybutynin were two-fold higher when the drug was administered after breakfast compared to the fasting state. Conclusion: Breakfast significantly reduced the MRT of oxybutynin and N-desethyloxybutynin. Springer-Verlag Berlin Heidelberg, 1996 Key words Oxybutynin nationallicence effect of food nationallicence N-desethyl oxybutynin nationallicence bioavailability nationallicence pharmacokinetics nationallicence Lukkari E. Leiras Oy, Clinical Research, P.O. Box 325, FIN-00101 Helsinki, Finland, FI aut Castrèn-Kortekangas P. Leiras Oy, Clinical Research, P.O. Box 325, FIN-00101 Helsinki, Finland, FI aut Juhakoski A. Leiras Oy, Bioanalytical Laboratory, Turku, Finland, FI aut Löyttyniemi E. Leiras Oy, Clinical Research, P.O. Box 325, FIN-00101 Helsinki, Finland, FI aut Aranko K. Leiras Oy, Clinical Research, P.O. Box 325, FIN-00101 Helsinki, Finland, FI aut Neuvonen P. J. Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland, FI aut https://doi.org/10.1007/s002280050096 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050096 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lukkari E. Leiras Oy, Clinical Research, P.O. Box 325, FIN-00101 Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Castrèn-Kortekangas P. Leiras Oy, Clinical Research, P.O. Box 325, FIN-00101 Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Juhakoski A. Leiras Oy, Bioanalytical Laboratory, Turku, Finland, FI aut NATIONALLICENCE 700 1- Löyttyniemi E. Leiras Oy, Clinical Research, P.O. Box 325, FIN-00101 Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Aranko K. Leiras Oy, Clinical Research, P.O. Box 325, FIN-00101 Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Neuvonen P. J. Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland, FI aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer