caa a22 4500 477057128 CHVBK 20180405111349.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/s002280050100 doi (NATIONALLICENCE)springer-10.1007/s002280050100 Stereoselective pharmacokinetics of mefloquine in young children [Elektronische Daten] [A. Bourahla, C. Martin, F. Gimenez, V. Singhasivanon, P. Attanath, A. Sabchearon, T. Chongsuphajaisiddhi, R. Farinotti] Objective: the stereospecificity of mefloquine pharmacokinetics in children has been investigated. Patients: Twelve children aged 6 to 24 months were treated for uncomplicated falciparum malaria with a single oral dose of 25 mg⋅kg−1 racemic mefloquine in combination with sulfadoxine and pyrimethamine. Methods: concentrations of mefloquine enantiomers were determined using a coupled achiral-chiral chromatographic system. Pharmacokinetic parameters were calculated using model-independent analysis. Results: Maximum plasma concentrations, areas under the curve and apparent plasma elimination half-lives were higher for the (−) enantiomer than its antipode. In contrast, the apparent volume of distribution (V/f) and total clearance (Cl/f) values were higher for the (+) enantiomer. Conclusion: the stereoselectivity of mefloquine pharmacokinetics is similar to that observed in adults. Springer-Verlag Berlin Heidelberg, 1996 Key words Mefloquine nationallicence Children nationallicence enantiomer nationallicence pharmacokinetics nationallicence stereoselectivity nationallicence Bourahla A. Hôpital Pitie Salpetriere Service Pharmacie 47, boulevard de l′hôpital F-75651 Paris Cedex 13, France, FR aut Martin C. Hôpital Pitie Salpetriere Service Pharmacie 47, boulevard de l′hôpital F-75651 Paris Cedex 13, France, FR aut Gimenez F. Hôpital Pitie Salpetriere Service Pharmacie 47, boulevard de l′hôpital F-75651 Paris Cedex 13, France, FR aut Singhasivanon V. Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, TH aut Attanath P. Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, TH aut Sabchearon A. Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, TH aut Chongsuphajaisiddhi T. Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, TH aut Farinotti R. Faculté de Pharmacie, Pharmacie Clinique, Chatenay Malabry, France, FR aut https://doi.org/10.1007/s002280050100 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050100 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bourahla A. Hôpital Pitie Salpetriere Service Pharmacie 47, boulevard de l′hôpital F-75651 Paris Cedex 13, France, FR aut NATIONALLICENCE 700 1- Martin C. Hôpital Pitie Salpetriere Service Pharmacie 47, boulevard de l′hôpital F-75651 Paris Cedex 13, France, FR aut NATIONALLICENCE 700 1- Gimenez F. Hôpital Pitie Salpetriere Service Pharmacie 47, boulevard de l′hôpital F-75651 Paris Cedex 13, France, FR aut NATIONALLICENCE 700 1- Singhasivanon V. Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, TH aut NATIONALLICENCE 700 1- Attanath P. Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, TH aut NATIONALLICENCE 700 1- Sabchearon A. Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, TH aut NATIONALLICENCE 700 1- Chongsuphajaisiddhi T. Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, TH aut NATIONALLICENCE 700 1- Farinotti R. Faculté de Pharmacie, Pharmacie Clinique, Chatenay Malabry, France, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer