caa a22 4500 477057136 CHVBK 20180405111349.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/s002280050087 doi (NATIONALLICENCE)springer-10.1007/s002280050087 Ketotifen in HIV-infected patients: effects on body weight and release of TNF-α [Elektronische Daten] [J. Ockenga, F. Rohde, U. Süttmann, L. Herbarth, M. Ballmaier, I. Schedel] Objective: Tumor necrosis factor alpha (TNF-α) is involved in the genesis of HIV-associated malnutrition. We performed an open-label trial on the effects of ketotifen, an in vitro inhibitor of TNF-α release from peripheral blood mononuclear cells (PBMCs), on the nutritional status and TNF-α release of HIV-infected subjects. Patients: Six HIV-infected subjects received oral ketotifen 4 mg per day for 84 days and were followed up for an additional 70-day period. Body composition was measured by bioelectrical impedance analysis. TNF-α plasma levels, TNF-α release from PBMCs, and plasma concentration of soluble TNF receptors were measured repeatedly during the study and control period. Results: During ketotifen intake, TNF-α release from stimulated PBMCs significantly decreased (68 vs 155 pg ml−1), but not TNF-α and soluble TNF receptor plasma concentrations. Subjects gained weight (+ 2.7 kg), whereas weight loss was observed after cessation of treatment (−1.6 kg). Conclusion: Ketotifen inhibits TNF-α release from stimulated PBMCs and might thus be useful in the management of HIV-associated malnutrition. Springer-Verlag Berlin Heidelberg, 1996 Key Words HIV infection nationallicence Ketotifen nationallicence nutritional status nationallicence Tumor Necrosis Factor alpha nationallicence Tumor Necrosis Factor Receptors nationallicence Ockenga J. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut Rohde F. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut Süttmann U. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut Herbarth L. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut Ballmaier M. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut Schedel I. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut https://doi.org/10.1007/s002280050087 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050087 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ockenga J. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut NATIONALLICENCE 700 1- Rohde F. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut NATIONALLICENCE 700 1- Süttmann U. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut NATIONALLICENCE 700 1- Herbarth L. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut NATIONALLICENCE 700 1- Ballmaier M. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut NATIONALLICENCE 700 1- Schedel I. Department of Clinical Immunology, Faculty of Internal Medicine and Dermatology, Medizinische Hochschule Hannover, D-30623 Hannover, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer