caa a22 4500 477057152 CHVBK 20180405111349.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/s002280050091 doi (NATIONALLICENCE)springer-10.1007/s002280050091 Adverse events with continuous doxapram infusion against late postoperative hypoxaemia [Elektronische Daten] [J. Rosenberg, P. A. Kristensen, M. H. Pedersen, H. Overgaard] Objective: A randomized double-blind controlled trial of doxapram versus placebo against late postoperative hypoxaemia was planned to include 40 patients (2 × 20). Results: After inclusion of 18 patients a serious adverse event was encountered with development of a brain stem infarction in a 90-year-old woman receiving doxapram. At this point the randomization code was broken and we decided to terminate the trial. Three of nine patients receiving doxapram had had an adverse event whereas none of the patients receiving placebo had adverse events (P = 0.2). In the 18 patients studied, there was an insignificant trend towards higher mean oxygen saturation in the doxapram group, and a significantly higher minimum oxygen saturation and reduced number of hypoxaemic events on the first postoperative night. Conclusion: Although these preliminary data on the effect of doxapram on postoperative hypoxaemia seem promising, further studies on the effect of continuous nocturnal postoperative doxapram infusion on levels of arterial oxygen saturation should be postponed until more knowledge about the pharmacokinetics of doxapram in this particular clinical situation has been gathered. Springer-Verlag Berlin Heidelberg, 1996 Key words Doxapram infusion nationallicence Hypoxaemia nationallicence Adverse events nationallicence postoperative nationallicence randomized nationallicence double-blind nationallicence controlled study nationallicence Rosenberg J. Department of Surgical Gastroenterology 235, Hvidovre University Hospital, DK-2650 Hvidovre, Denmark, DK aut Kristensen P. A. Department of Anaesthesiology, Hvidovre University Hospital, DK-2650 Hvidovre, Denmark, DK aut Pedersen M. H. Department of Anaesthesiology, Sundby Hospital, DK-2300 Copenhagen, Denmark, DK aut Overgaard H. Department of General Surgery, Sundby Hospital, DK-2300 Copenhagen, Denmark, DK aut https://doi.org/10.1007/s002280050091 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050091 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rosenberg J. Department of Surgical Gastroenterology 235, Hvidovre University Hospital, DK-2650 Hvidovre, Denmark, DK aut NATIONALLICENCE 700 1- Kristensen P. A. Department of Anaesthesiology, Hvidovre University Hospital, DK-2650 Hvidovre, Denmark, DK aut NATIONALLICENCE 700 1- Pedersen M. H. Department of Anaesthesiology, Sundby Hospital, DK-2300 Copenhagen, Denmark, DK aut NATIONALLICENCE 700 1- Overgaard H. Department of General Surgery, Sundby Hospital, DK-2300 Copenhagen, Denmark, DK aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer