caa a22 4500 477057187 CHVBK 20180405111349.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/s002280050089 doi (NATIONALLICENCE)springer-10.1007/s002280050089 Effects of oral contraceptives on plasma neutral amino acids and cholesterol during a menstrual cycle [Elektronische Daten] [S. E. Møller, B. Maach-Møller, M. Olesen, B. Fjalland] Objective: Concentrations of plasma neutral amino acids, i.e. threonine, serine, asparagine, glycine, alanine, citrulline, α-aminobutyric acid, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, and tryptophan, and serum cholesterol, were determined at the follicular (Day 4), mid-cycle (Day 16) and luteal (Day 25) phases of the menstrual cycle in 15 users of the new generation of combined oral contraceptives (OC), 11 on multiphase combined OC, and 17 controls. Results: The controls showed a decrease in the sum of amino acids to 95% at mid-cycle and 90% in the luteal phase relative to the follicular phase, and a significant decrease in the tyrosine level at the luteal relative to the follicular phase. Since there was no significant difference between the two OC subgroups in the levels of the specified variables at either of the phases, the two groups were considered together. The sum of amino acids in the OC group decreased to 89% at mid-cycle and 91% at the luteal phase relative to the follicular phase, indicating less metabolic effect than reported for older OC formulations. Compared to the controls, the OC group showed significant increased threonine level at the luteal phase, decreased glycine levels at mid-cycle and the luteal phases, decreased citrulline level at mid-cycle, and markedly decreased tyrosine levels at the mid-cycle and luteal phases. Neither total nor high density lipoprotein (HDL) cholesterol differed significantly between the control and OC groups. Conclusion: The results suggest that the metabolic effects of the new generation combined OC on neutral amino acids and cholesterol are only modest to slight, except for the effect on tyrosine, the brain noradrenaline precursor, which may cause disturbances of various noradrenaline-mediated central functions in susceptible subjects. Springer-Verlag Berlin Heidelberg, 1996 Key words Oral contraceptives nationallicence Neutral amino acids nationallicence Menstrual cycle nationallicence Cholesterol nationallicence tyrosine nationallicence Møller S. E. Department of Clinical Pharmacology, St. Hans Psychiatric Hospital, Roskilde, Denmark, DK aut Maach-Møller B. Institute of Biology, Royal Danish School of Pharmacy, Copenhagen Ø, Denmark, DK aut Olesen M. Institute of Biology, Royal Danish School of Pharmacy, Copenhagen Ø, Denmark, DK aut Fjalland B. Institute of Biology, Royal Danish School of Pharmacy, Copenhagen Ø, Denmark, DK aut https://doi.org/10.1007/s002280050089 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050089 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Møller S. E. Department of Clinical Pharmacology, St. Hans Psychiatric Hospital, Roskilde, Denmark, DK aut NATIONALLICENCE 700 1- Maach-Møller B. Institute of Biology, Royal Danish School of Pharmacy, Copenhagen Ø, Denmark, DK aut NATIONALLICENCE 700 1- Olesen M. Institute of Biology, Royal Danish School of Pharmacy, Copenhagen Ø, Denmark, DK aut NATIONALLICENCE 700 1- Fjalland B. Institute of Biology, Royal Danish School of Pharmacy, Copenhagen Ø, Denmark, DK aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer