caa a22 4500 477057217 CHVBK 20180405111349.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/s002280050084 doi (NATIONALLICENCE)springer-10.1007/s002280050084 Once-daily gentamicin: translating theory into practice [Elektronische Daten] [R. Cunningham, H. Humphreys] Gentamicin continues to have an important role in the treatment of serious bacterial infections. There is increasing interest in once-daily administration, which is more convenient than multiple-dose regimens. Animal studies and clinical trials suggest that once-daily administration is as efficacious and no more toxic for a variety of infections, but there is still some reluctance to use once-daily regimens routinely in neutropenic patients, because of the potential risk of breakthrough bacteraemia. A number of aspects of the serum concentration monitoring of once-daily gentamicin remain unresolved. The most commonly used assay systems are not sensitive enough, without some modification in technique, to detect the very small pre-dose concentrations seen with once-daily dosing, and it is not clear what constitutes an acceptable pre-dose concentration. Until the results from further studies become available, it is prudent to maintain a pre-dose concentration below 1 mg ⋅l−1, and local arrangements are necessary to address the frequency and timing of assays. It seems likely that once-daily administration will become the norm, because of its many advantages. Springer-Verlag Berlin Heidelberg, 1996 Key wordsGentamicin nationallicence aminoglycoside antibiotics nationallicence administration and dosage nationallicence serum assays nationallicence Cunningham R. Public Health Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK, GB aut Humphreys H. Division of Microbiology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK, GB aut https://doi.org/10.1007/s002280050084 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050084 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cunningham R. Public Health Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK, GB aut NATIONALLICENCE 700 1- Humphreys H. Division of Microbiology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer