caa a22 4500 477057225 CHVBK 20180405111349.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/s002280050118 doi (NATIONALLICENCE)springer-10.1007/s002280050118 A single dose of ursodiol does not affect cyclosporine absorption in liver transplant patients [Elektronische Daten] [C. W. Maboundou, G. Paintaud, C. Vanlemmens, J. Magnette, S. Bresson-Hadni, G. Mantion, J. P. Miguet, P. R. Bechtel] Objective: To study the possible influence of ursodiol (ursodeoxycholic acid), a hydrophilic bile acid, on cyclosporine (CsA) bioavailability. Methods: Seven adult liver transplant recipients participated in a randomised cross-over pharmacokinetic study comparing ursodiol (600 mg) with placebo in single doses. Blood concentrations of CsA were measured by HPLC. Results: There was no significant effect of ursodiol on CsA absorption: AUC was 5011 vs 5486 ng⋅h⋅ml-1, Cmax was 832 vs 871 ng⋅ml-1 and tmax was 2 vs 2 h, after ursodiol and placebo, respectively. Conclusion: Although a significant period effect was observed, we conclude that a single dose of ursodiol has little effect on CsA absorption in liver transplant patients and that an interaction in the intestinal lumen between these two drugs is unlikely. Springer-Verlag Berlin Heidelberg, 1996 Key words Cyclosporine nationallicence Ursodiol nationallicence ursodeoxycholic acid nationallicence absorption nationallicence pharmacokinetics nationallicence liver transplantation nationallicence Maboundou C. W. Department of Clinical Pharmacology, Besançon University Hospital, F-25030 Besançon, France, FR aut Paintaud G. Department of Clinical Pharmacology, Besançon University Hospital, F-25030 Besançon, France, FR aut Vanlemmens C. Liver Transplant Unit, Besançon University Hospital, France, FR aut Magnette J. Department of Clinical Pharmacology, Besançon University Hospital, F-25030 Besançon, France, FR aut Bresson-Hadni S. Liver Transplant Unit, Besançon University Hospital, France, FR aut Mantion G. Liver Transplant Unit, Besançon University Hospital, France, FR aut Miguet J. P. Liver Transplant Unit, Besançon University Hospital, France, FR aut Bechtel P. R. Department of Clinical Pharmacology, Besançon University Hospital, F-25030 Besançon, France, FR aut https://doi.org/10.1007/s002280050118 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050118 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maboundou C. W. Department of Clinical Pharmacology, Besançon University Hospital, F-25030 Besançon, France, FR aut NATIONALLICENCE 700 1- Paintaud G. Department of Clinical Pharmacology, Besançon University Hospital, F-25030 Besançon, France, FR aut NATIONALLICENCE 700 1- Vanlemmens C. Liver Transplant Unit, Besançon University Hospital, France, FR aut NATIONALLICENCE 700 1- Magnette J. Department of Clinical Pharmacology, Besançon University Hospital, F-25030 Besançon, France, FR aut NATIONALLICENCE 700 1- Bresson-Hadni S. Liver Transplant Unit, Besançon University Hospital, France, FR aut NATIONALLICENCE 700 1- Mantion G. Liver Transplant Unit, Besançon University Hospital, France, FR aut NATIONALLICENCE 700 1- Miguet J. P. Liver Transplant Unit, Besançon University Hospital, France, FR aut NATIONALLICENCE 700 1- Bechtel P. R. Department of Clinical Pharmacology, Besançon University Hospital, F-25030 Besançon, France, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer