caa a22 4500 477057276 CHVBK 20180405111349.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/s002280050116 doi (NATIONALLICENCE)springer-10.1007/s002280050116 Absolute bioavailability of fluoride from disodium monofluorophosphate and enteric-coated sodium fluoride tablets [Elektronische Daten] [P. van Asten, S. A. Duursma, J. H. Glerum, F. F. T. Ververs, H. J. M. van Rijn, A. van Dijk] Objectives: The absolute bioavailability and other pharmacokinetic parameters of two fluoride formulations were investigated in 13 healthy volunteers, aged 61-70 years. Methods: The following formulations were administered, under fasting conditions, in a single-dose three-way cross-over design: tablets of 76 mg disodium monofluoro phosphate (MFP, equivalent to 10.0 mg F− ion), enteric-coated (e.c.) tablets of 25 mg sodium fluoride (NaFor, equivalent of 11.3 mg F− ion), and an isoosmotic aqueous injection solution (4 ml) of 22.1 mg sodium fluoride (NaFiv, equivalent of 10.0 mg F− ion). There was a wash-out period of at least one week between each administration. Blood was sampled before and during a 24-hour period after administration. For F− excretion urine was sampled 48 hours before (baseline) and over the 48 hours after the adminstration. Results: The mean t1/2 values of the three formulations were 8.3, 8.7 and 8.3 h for MFP, NaFor and NaFiv respectively, and were not significant different. Mean Cmax after MFP was significantly higher than after NaFor [344 vs 142 μg⋅l−1]. Mean tmax for MFP was shorter than for NaFor [1.1 vs 4.6 h]. MFP had significantly higher bioavailability [102.8%] than NaFor [64.2%]. Conclusion: The MFP formulation showed higher bioavailability with smaller variation than the NaFor formulation. MFP is preferable, therefore, for fluoride therapy in clinical practice, and changing from NaFor to MFP will require adjustment of the dose. Springer-Verlag Berlin Heidelberg, 1996 Key words Sodium fluoride nationallicence Disodium monofluorophosphate nationallicence absolute bioavailability nationallicence pharmacokinetics nationallicence elderly population nationallicence van Asten P. Department of Hospital Pharmacy, Utrecht University Hospital, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands, NL aut Duursma S. A. Department of Geriatrics, Utrecht University Hospital, Utrecht, The Netherlands, NL aut Glerum J. H. Department of Hospital Pharmacy, Utrecht University Hospital, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands, NL aut Ververs F. F. T. Department of Hospital Pharmacy, Utrecht University Hospital, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands, NL aut van Rijn H. J. M. Department of Clinical Chemistry, Utrecht University Hospital, Utrecht, The Netherlands, NL aut van Dijk A. Department of Hospital Pharmacy, Utrecht University Hospital, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands, NL aut https://doi.org/10.1007/s002280050116 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050116 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Asten P. Department of Hospital Pharmacy, Utrecht University Hospital, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands, NL aut NATIONALLICENCE 700 1- Duursma S. A. Department of Geriatrics, Utrecht University Hospital, Utrecht, The Netherlands, NL aut NATIONALLICENCE 700 1- Glerum J. H. Department of Hospital Pharmacy, Utrecht University Hospital, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands, NL aut NATIONALLICENCE 700 1- Ververs F. F. T. Department of Hospital Pharmacy, Utrecht University Hospital, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands, NL aut NATIONALLICENCE 700 1- van Rijn H. J. M. Department of Clinical Chemistry, Utrecht University Hospital, Utrecht, The Netherlands, NL aut NATIONALLICENCE 700 1- van Dijk A. Department of Hospital Pharmacy, Utrecht University Hospital, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands, NL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer