caa a22 4500 477057284 CHVBK 20180405111350.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/s002280050111 doi (NATIONALLICENCE)springer-10.1007/s002280050111 Pharmacokinetics and absolute bioavailability of lansoprazole [Elektronische Daten] [J. Gerloff, A. Mignot, H. Barth, K. Heintze] Objective: In a crossover study 12 healthy volunteers received lansoprazole 15 mg or 30 mg orally, or 15 mg intravenously in randomized order as a single dose. Blood samples were taken and plasma levels of lansoprazole were determined using an HPLC method. The volunteers were phenotyped for the debrisoquine/sparteine and mephenytoin polymorphisms. Results: The total clearance was 517 ml⋅min−1, and the absolute bioavailability was 91% for the 30-mg and 81% for the 15-mg enteric-coated formulation. The elimination half-life was about 1 h. No correlation of the plasma levels to the sparteine metabolic ratio was found, and no correlation to the mephenytoin type could be established, since all volunteers of the mephenytoin type were extensive metabolizers. Although considerable variation, inter- and intraindividually, was observed, the increase in cmax and AUC did not deviate from dose proportionality. The present galenic formulation ensures a high bioavailability after a single dose. Springer-Verlag Berlin Heidelberg, 1996 Key words Lansoprazole nationallicence pharmacokinetics nationallicence absolute bioavailability nationallicence debrisoquine/sparteine phenotype nationallicence mephenytoin phenotype nationallicence Gerloff J. Department of Clinical Pharmacology, Gruenenthal GmbH, Zieglerstrasse 6, D-52078 Aachen, Germany, DE aut Mignot A. CEPHAC Analytical, F-86280 St. Benoit, France, FR aut Barth H. Department of Clinical Pharmacology, Gruenenthal GmbH, Zieglerstrasse 6, D-52078 Aachen, Germany, DE aut Heintze K. Department of Clinical Pharmacology, Gruenenthal GmbH, Zieglerstrasse 6, D-52078 Aachen, Germany, DE aut https://doi.org/10.1007/s002280050111 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050111 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gerloff J. Department of Clinical Pharmacology, Gruenenthal GmbH, Zieglerstrasse 6, D-52078 Aachen, Germany, DE aut NATIONALLICENCE 700 1- Mignot A. CEPHAC Analytical, F-86280 St. Benoit, France, FR aut NATIONALLICENCE 700 1- Barth H. Department of Clinical Pharmacology, Gruenenthal GmbH, Zieglerstrasse 6, D-52078 Aachen, Germany, DE aut NATIONALLICENCE 700 1- Heintze K. Department of Clinical Pharmacology, Gruenenthal GmbH, Zieglerstrasse 6, D-52078 Aachen, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer