caa a22 4500 477057349 CHVBK 20180405111350.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/s002280050106 doi (NATIONALLICENCE)springer-10.1007/s002280050106 Reproducibility of airway response to inhaled bradykinin and effect of the neurokinin receptor antagonist FK-24 in asthmatic subjects [Elektronische Daten] [D. Schmidt, R. A. Jörres, K. F. Rabe, H. Magnussen] Objective: Inhaled neurokinins have been shown to induce bronchoconstriction in asthmatic subjects. We have investigated the effect of a neurokinin receptor antagonist, FK-224, on bradykinin (BK)-induced bronchoconstriction, and have compared its effect with the spontaneous variability of BK responsiveness. Methods: Thirteen subjects with mild extrinsic bronchial asthma participated in the study. Four BK inhalation challenge tests (Study Days 2 to 5) were performed over a period of several weeks. On Study Days 4 and 5 subjects inhaled either 2 mg FK-224 or placebo 30 min before the BK challenge. Results: The geometric mean PC20FEV1 of BK was 0.04, 0.06, and 0.10 mg⋅ml−1 on the first and second BK challenge and after placebo. Mean PC20FEV1 after FK-224 was 0.20 mg⋅ml−1 and was not different from placebo, whereas there was a significant effect in PC15FEV1. The mean shift in PC20FEV1 after FK-224 vs placebo was 1.0 doubling concentrations. The mean changes in BK responsiveness on the second BK challenge and placebo days compared to the first BK challenge were 0.6 and 1.3 doubling concentrations. We observed a significant fall in FEV1 after inhalation of saline plus ethanol, which was the diluent for BK (mean decrease 4.2%). Conclusion: The data demonstrate that inhalation of 2 mg FK-224 is only marginally effective against BK-induced bronchoconstriction in mild asthmatic subjects and that its effect is similar to the variability in BK responsiveness assessed over several weeks. Springer-Verlag Berlin Heidelberg, 1996 Key words Airway hyperresponsiveness nationallicence Bradykinin nationallicence bronchial challenge nationallicence neurokinins nationallicence ethanol nationallicence bronchoconstriction nationallicence lung function nationallicence FK-224 nationallicence Schmidt D. Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, LVA - Freie und Hansestadt Hamburg, Wöhrendamm 80, D-22927 Grosshansdorf, Germany, DE aut Jörres R. A. Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, LVA - Freie und Hansestadt Hamburg, Wöhrendamm 80, D-22927 Grosshansdorf, Germany, DE aut Rabe K. F. Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, LVA - Freie und Hansestadt Hamburg, Wöhrendamm 80, D-22927 Grosshansdorf, Germany, DE aut Magnussen H. Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, LVA - Freie und Hansestadt Hamburg, Wöhrendamm 80, D-22927 Grosshansdorf, Germany, DE aut https://doi.org/10.1007/s002280050106 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050106 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schmidt D. Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, LVA - Freie und Hansestadt Hamburg, Wöhrendamm 80, D-22927 Grosshansdorf, Germany, DE aut NATIONALLICENCE 700 1- Jörres R. A. Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, LVA - Freie und Hansestadt Hamburg, Wöhrendamm 80, D-22927 Grosshansdorf, Germany, DE aut NATIONALLICENCE 700 1- Rabe K. F. Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, LVA - Freie und Hansestadt Hamburg, Wöhrendamm 80, D-22927 Grosshansdorf, Germany, DE aut NATIONALLICENCE 700 1- Magnussen H. Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, LVA - Freie und Hansestadt Hamburg, Wöhrendamm 80, D-22927 Grosshansdorf, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer