caa a22 4500 477057438 CHVBK 20180405111350.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/s002280050062 doi (NATIONALLICENCE)springer-10.1007/s002280050062 Time course of physical and psychological responses to selegiline monotherapy in newly diagnosed, idiopathic parkinosonism [Elektronische Daten] [C. Kirollos, A. Charlett, S. G. Bowes, A. G. Purkiss, C. J. A. O'Neill, C. Weller, J. Dickins, G. Faulkner, P. W. Nicholson, W. B. Hunt, R. J. Dobbs, S. M. Dobbs] Abstract.: Rationale: Poor specificity of face-value endpoints and the poor sensitivity of gross clinical examination may have militated against demonstrating prophylaxis by selegiline. Methods: Objective measures of the four cardinal signs were used as primary outcome criteria in a randomised, double-blind, placebo-controlled, parallel group study of selegiline monotherapy in 25 newly diagnosed elderly sufferers from idiopathic parkinsonism, stratified for sex and Hoehn and Yahr functional staging. Results: There was a significant interaction between time and nature of treatment with respect to rigidity. The effect of time during active treatment was highly significant: rigidity decreased by 1.3 % per week. The worsening of rigidity on placebo was not statistically significant. Neuronal rescue is a possible explanation for the long term, progressive improvement produced by selegiline. No significant treatment effect was seen on the other cardinal signs. However, there was a significant quadratic time trend for arousal on active treatment suggesting tolerance to this effect. Conclusion: The difference in time course between the psychostimulant and physical effects suggests more than one mode of action. Springer-Verlag Berlin Heidelberg, 1996 Key words Selegiline nationallicence Parkinsonian nationallicence monotherapy nationallicence placebo nationallicence newly diagnosed elderly nationallicence objective assessment nationallicence Kirollos C. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut Charlett A. Statistics Unit, Public Health Laboratory Service Communicable Disease Surveillance Centre, London, XX aut Bowes S. G. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut Purkiss A. G. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut O'Neill C. J. A. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut Weller C. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut Dickins J. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut Faulkner G. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut Nicholson P. W. The University College and Middlesex School of Medicine, London, XX aut Hunt W. B. University of Hertfordshire, Hatfield, Hertfordshire, UK, GB aut Dobbs R. J. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut Dobbs S. M. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut https://doi.org/10.1007/s002280050062 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050062 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kirollos C. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut NATIONALLICENCE 700 1- Charlett A. Statistics Unit, Public Health Laboratory Service Communicable Disease Surveillance Centre, London, XX aut NATIONALLICENCE 700 1- Bowes S. G. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut NATIONALLICENCE 700 1- Purkiss A. G. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut NATIONALLICENCE 700 1- O'Neill C. J. A. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut NATIONALLICENCE 700 1- Weller C. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut NATIONALLICENCE 700 1- Dickins J. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut NATIONALLICENCE 700 1- Faulkner G. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut NATIONALLICENCE 700 1- Nicholson P. W. The University College and Middlesex School of Medicine, London, XX aut NATIONALLICENCE 700 1- Hunt W. B. University of Hertfordshire, Hatfield, Hertfordshire, UK, GB aut NATIONALLICENCE 700 1- Dobbs R. J. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut NATIONALLICENCE 700 1- Dobbs S. M. Therapeutics in the Elderly, The Hillingdon Hospital and Brunel University Postgraduate and Research Centre, Pield Heath Rd., Uxbridge, Middlesex UB8 3NN, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer