caa a22 4500 477057454 CHVBK 20180405111350.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/s002280050066 doi (NATIONALLICENCE)springer-10.1007/s002280050066 Influence of age on venodilator effect of isoproterenol and amrinone [Elektronische Daten] [K. Harada, K. Ohashi, Y. Kumagai, M. Ohmori, A. Fujimura] Objective: To investigate the influence of age on the venodilator effect of isoproterenol, a β-adrenoceptor agonist, and amrinone, a selective phosphodiesterase (PDE) III inhibitor, in human subjects. Methods: In eight young and eight elderly male subjects, the drugs were infused into a dorsal hand vein preconstricted with phenylephrine and its diameter was measured using a linear variable differential transformer. Results: The maximum venodilation (Emax) induced by isoproterenol was significantly smaller and the infusion rate of isoproterenol required to induce 50% of maximum venodilation (ED50) was significantly larger in the elderly than in the young subjects [Emax: 29.8 vs 95.1%, ED50: 97.3 vs 51.6 ng ⋅min-1]. A significant age-related change in Emax or ED50 was not observed for amrinone (Emax: 95.8 vs 100.8%, ED50: 40.1 vs 31.6 μg ⋅min-1). Conclusion: The data show that the venodilator effect of amrinone is not influenced by age. As amrinone increases cyclic AMP by inhibition of PDE III, it is suggested that the action of cyclic AMP is not altered by age. The decreased effect of isoproterenol might be caused by reduced production of cyclic AMP in elderly subjects. Springer-Verlag Berlin Heidelberg, 1996 Key words Isoproterenol nationallicence Amrinone nationallicence Elderly nationallicence venodilation nationallicence age-related change nationallicence dorsal hand vein technique nationallicence Harada K. Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun Tochigi 329-04 Japan, JP aut Ohashi K. Department of Clinical Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan, JP aut Kumagai Y. Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun Tochigi 329-04 Japan, JP aut Ohmori M. Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun Tochigi 329-04 Japan, JP aut Fujimura A. Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun Tochigi 329-04 Japan, JP aut https://doi.org/10.1007/s002280050066 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050066 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Harada K. Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun Tochigi 329-04 Japan, JP aut NATIONALLICENCE 700 1- Ohashi K. Department of Clinical Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan, JP aut NATIONALLICENCE 700 1- Kumagai Y. Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun Tochigi 329-04 Japan, JP aut NATIONALLICENCE 700 1- Ohmori M. Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun Tochigi 329-04 Japan, JP aut NATIONALLICENCE 700 1- Fujimura A. Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun Tochigi 329-04 Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer