caa a22 4500 477057470 CHVBK 20180405111350.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/s002280050072 doi (NATIONALLICENCE)springer-10.1007/s002280050072 The effect of hypoxaemia on drug disposition in chronic respiratory failure [Elektronische Daten] [D. Rowett, K. Latimer, L. N. Sansom, R. E. Ruffin, F. May, G. Henderson, P. J. Hayball, Received: February 1995/Accepted May] Objective: The influence of hypoxaemia on the disposition of two common drugs has been examined in ten adults with stable chronic respiratory failure. Methods: There were two experimental periods in this cross-over study: during these periods supplemental oxygen was either withheld or administered to impose clinical hypoxaemia or maintain normoxaemia, respectively. Each participant received either oral (40 mg) or intravenous (20 mg) frusemide combined with oral paracetamol (500 mg) on consecutive days of the two experimental periods. Results: The total (bound plus unbound) plasma clearance of frusemide during hypoxaemia (arterial oxygen tension, PaO2 ≤ 50 Torr) was not significantly different from the value during normoxaemia (PaO2 ≥ 60 Torr) [76.9 and 62.4 ml ⋅ min−1]. The volume of distribution was not affected by acute hypoxaemia (121 ml ⋅ kg−1 without and 109 ml ⋅ kg−1 with oxygen; P > 0.05). Renal and non-renal clearances of frusemide were similar during the period of hypoxaemia (31 and 38 ml ⋅ min−1, respectively) compared to respective values during supplemental oxygen delivery (29 and 32 ml ⋅ min−1). The absolute bioavailability of frusemide during hypoxaemia (0.62) was not different to that obtained during normoxaemia (0.56). The combined sodium and potassium excretion rate (expressed as a function of the frusemide excretion rate) was not altered by changing the oxygen tension. The pharmacokinetics of paracetamol were unaffected by hypoxaemia. Springer-Verlag Berlin Heidelberg, 1996 Key words Hypoxaemia nationallicence Pharmacokinetics nationallicence Pharmacodynamics nationallicence frusemide nationallicence paracetamol nationallicence Rowett D. Pharmacy Department, Repatriation General Hospital, Daw Park, Adelaide, South Australia 5041, Australia, AU aut Latimer K. Department of Respiratory Medicine, Flinders Medical Centre, Bedford Park, Adelaide, South Australia 5041, Australia, AU aut Sansom L. N. School of Pharmacy, University of South Australia, Adelaide, South Australia, Australia, AU aut Ruffin R. E. Department of Respiratory Medicine, Flinders Medical Centre, Bedford Park, Adelaide, South Australia 5041, Australia, AU aut May F. Pharmacy Department, Repatriation General Hospital, Daw Park, Adelaide, South Australia 5041, Australia, AU aut Henderson G. Department of Respiratory Medicine, Flinders Medical Centre, Bedford Park, Adelaide, South Australia 5041, Australia, AU aut Hayball P. J. Pharmacy Department, Repatriation General Hospital, Daw Park, Adelaide, South Australia 5041, Australia, AU aut May Received: February 1995/Accepted Pharmacy Department, Repatriation General Hospital, Daw Park, Adelaide, South Australia 5041, Australia, AU aut https://doi.org/10.1007/s002280050072 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050072 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rowett D. Pharmacy Department, Repatriation General Hospital, Daw Park, Adelaide, South Australia 5041, Australia, AU aut NATIONALLICENCE 700 1- Latimer K. Department of Respiratory Medicine, Flinders Medical Centre, Bedford Park, Adelaide, South Australia 5041, Australia, AU aut NATIONALLICENCE 700 1- Sansom L. N. School of Pharmacy, University of South Australia, Adelaide, South Australia, Australia, AU aut NATIONALLICENCE 700 1- Ruffin R. E. Department of Respiratory Medicine, Flinders Medical Centre, Bedford Park, Adelaide, South Australia 5041, Australia, AU aut NATIONALLICENCE 700 1- May F. Pharmacy Department, Repatriation General Hospital, Daw Park, Adelaide, South Australia 5041, Australia, AU aut NATIONALLICENCE 700 1- Henderson G. Department of Respiratory Medicine, Flinders Medical Centre, Bedford Park, Adelaide, South Australia 5041, Australia, AU aut NATIONALLICENCE 700 1- Hayball P. J. Pharmacy Department, Repatriation General Hospital, Daw Park, Adelaide, South Australia 5041, Australia, AU aut NATIONALLICENCE 700 1- May Received: February 1995/Accepted Pharmacy Department, Repatriation General Hospital, Daw Park, Adelaide, South Australia 5041, Australia, AU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer