caa a22 4500 477057535 CHVBK 20180405111350.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/s002280050065 doi (NATIONALLICENCE)springer-10.1007/s002280050065 Xamoterol improves right ventricular systolic and diastolic function in pulmonary heart disease [Elektronische Daten] [R. M. Oliver, J. S. Fleming, D. G. Waller] Abstract.: Objective: Abnormal right ventricular function in patients with pulmonary heart disease (PHD) may contribute to their reduced exercise capacity. We have evaluated the effect of subacute dosing with xamoterol, a beta-1 adrenoreceptor partial agonist with inotropic properties, on right ventricular function in patients with PHD. Patients: Twelve patients with advanced chronic obstructive pulmonary disease and clinical evidence of PHD received xamoterol 200 mg twice daily or placebo for 7 days in a randomised double-blind crossover study. Right heart krypton-81m radionuclide ventriculography was used to derive right ventricular ejection fraction (RVEF) both at rest and during submaximal exercise, and indices of right ventricular systolic and diastolic function at rest. Results: During treatment with placebo, mean RVEF was 0.53 at rest and was unchanged during exercise. After xamoterol, mean RVEF was 0.55 at rest and increased to 0.59 during exercise. Xamoterol increased right ventricular peak ejection rate from 3.04 to 3.45 EDV⋅s-1 and mean early diastolic filling rate from 1.00 to 1.20 EDV⋅s-1. Conclusion: Subacute treatment with xamoterol in patients with PHD improves right ventricular systolic and diastolic function at rest and results in a favourable augmentation in right ventricular function during submaximal exercise. Springer-Verlag Berlin Heidelberg, 1996 Key words Pulmonary heart disease nationallicence Xamoterol nationallicence right ventricular function nationallicence radionuclide ventriculography nationallicence Oliver R. M. Clinical Pharmacology Group, University of Southampton, Southampton, UK, GB aut Fleming J. S. Department of Nuclear Medicine, Southampton General Hospital, Southampton, UK, GB aut Waller D. G. Clinical Pharmacology Group, University of Southampton, Southampton, UK, GB aut https://doi.org/10.1007/s002280050065 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050065 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oliver R. M. Clinical Pharmacology Group, University of Southampton, Southampton, UK, GB aut NATIONALLICENCE 700 1- Fleming J. S. Department of Nuclear Medicine, Southampton General Hospital, Southampton, UK, GB aut NATIONALLICENCE 700 1- Waller D. G. Clinical Pharmacology Group, University of Southampton, Southampton, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer