caa a22 4500 477057551 CHVBK 20180405111351.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/s002280050071 doi (NATIONALLICENCE)springer-10.1007/s002280050071 Metabolism of paracetamol in children with chronic liver disease [Elektronische Daten] [S. S. Al-Obaidy, P. J. McKiernan, A. Li Wan Po, J. F. T. Glasgow, P. S. Collier] Objective: To study the metabolism of single doses of paracetamol in paediatric patients with chronic liver disease admitted to a hospital liver disease clinic. Results: Thirteen paediatric patients, aged 7 months to 12 years, with chronic liver disease of varying severity were studied. In these children, paracetamol elimination half-life was negatively correlated with serum albumin and positively with prothrombin time, as previously reported in adults with liver disease. The rate constant of glucuronide formation was higher in the children with liver disease compared to the value reported in healthy children of similar ages. The rate constant of the formation of paracetamol sulphate was no different from that in normal children. The 36 h urinary paracetamol glucuronide to sulphate ratio was 1.4 (95% CI 0.8 to 1.7). This mean ratio was higher than in healthy children (0.81 and 0.75) but not significantly so, probably because of a Type 1 error due to the inevitable small sample size arising from the nature of the population being studied. Conclusion: The present study provides reassuring additional data to indicate that, at least for single doses, there is no cause for concern in the use of paracetamol in children with chronic liver disease. Springer-Verlag Berlin Heidelberg, 1996 Key words Acetaminophen nationallicence Liver disease in children nationallicence toxicity nationallicence analgesics nationallicence antipyretics pharmacokinetics nationallicence Al-Obaidy S. S. The School of Pharmacy, The Queen's University of Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, IE aut McKiernan P. J. The Department of Child Health, Royal Belfast Hospital for Sick Children, Belfast, BT12 6BE, Northern Ireland, IE aut Po A. Li Wan The School of Pharmacy, The Queen's University of Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, IE aut Glasgow J. F. T. The Department of Child Health, Royal Belfast Hospital for Sick Children, Belfast, BT12 6BE, Northern Ireland, IE aut Collier P. S. The School of Pharmacy, The Queen's University of Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, IE aut https://doi.org/10.1007/s002280050071 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050071 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Al-Obaidy S. S. The School of Pharmacy, The Queen's University of Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, IE aut NATIONALLICENCE 700 1- McKiernan P. J. The Department of Child Health, Royal Belfast Hospital for Sick Children, Belfast, BT12 6BE, Northern Ireland, IE aut NATIONALLICENCE 700 1- Po A. Li Wan The School of Pharmacy, The Queen's University of Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, IE aut NATIONALLICENCE 700 1- Glasgow J. F. T. The Department of Child Health, Royal Belfast Hospital for Sick Children, Belfast, BT12 6BE, Northern Ireland, IE aut NATIONALLICENCE 700 1- Collier P. S. The School of Pharmacy, The Queen's University of Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, IE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer