caa a22 4500 477057594 CHVBK 20180405111351.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/s002280050077 doi (NATIONALLICENCE)springer-10.1007/s002280050077 Measurement of 5-fluorouracil in scalp hair: a possible index of patient compliance with oral adjuvant chemotherapy [Elektronische Daten] [T. Uematsu, M. Nakashima, M. Fujii, K. Hamano, M. Yasutomi, S. Kodaira, T. Kato, K. Kotake, H. Oka, T. Masuike] Abstract.:  Objective: Little is known about patient compliance with oral adjuvant chemotherapy. It is estimated to be poor especially in Japan, where it is still unusual for patients to be directly informed of their diagnosis of malignancy. 5-Fluorouracil (5-FU) was measured in hair samples to assess patient exposure to 5-FU, and its potential usefulness is discussed as an index of compliance with postoperative adjuvant chemotherapy. Methods: Hair samples obtained from 55 patients, who had received oral 5-FU (total dose 27-41 g) as postoperative adjuvant chemotherapy over a 6-month period, were used for the analysis of 5-FU. The drug was extracted from the hair using ethyl acetate, and its fluorescence derivatization was employed for measurement with HPLC. The detection limit of 5-FU in hair was 0.01 ppm. Results: In 22 out of 55 samples 5-FU content was under the detection limit, whereas in the remaining 33 samples the drug was detected in a range of 0.006-2.125 ng per hair strand; in addition, drug content showed a log-normal distribution. 5-FU was detected in the hair collected from those patients who were possibly compliant with the postoperative oral adjuvant chemotherapy. Conclusion: As many as 40% of the patients analysed were supposed to be much less compliant. Even in the possibly compliant patients, the degree of compliance with the therapy varied according to a log-normal distribution. Springer-Verlag Berlin Heidelberg, 1996 Key words 5-Fluorouracil nationallicence Hair analysis nationallicence adjuvant chemotherapy nationallicence oral administration nationallicence compliance nationallicence Uematsu T. Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500, Japan, JP aut Nakashima M. Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan, JP aut Fujii M. Third Department of Surgery, Nihon University School of Medicine, Tokyo, Japan, JP aut Hamano K. Second Department of Surgery, Tokyo Women's Medical College, Tokyo, Japan, JP aut Yasutomi M. First Department of Surgery, Kinki University School of Medicine, Osaka-Sayama, Japan, JP aut Kodaira S. Department of Surgery, Keio University School of Medicine, Tokyo, Japan, JP aut Kato T. Department of Surgery, Aichi Cancer Center, Nagoya, Japan, JP aut Kotake K. Department of Surgery, Tochigi Cancer Center, Utsunomiya, Japan, JP aut Oka H. Department of Surgery, Showa University Fujigaoka Hospital, Tokyo, Japan, JP aut Masuike T. Analytical Research Laboratory, Kyowa Hakko Kogyo Co. Ltd., Mishima, Japan, JP aut https://doi.org/10.1007/s002280050077 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050077 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uematsu T. Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500, Japan, JP aut NATIONALLICENCE 700 1- Nakashima M. Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan, JP aut NATIONALLICENCE 700 1- Fujii M. Third Department of Surgery, Nihon University School of Medicine, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Hamano K. Second Department of Surgery, Tokyo Women's Medical College, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Yasutomi M. First Department of Surgery, Kinki University School of Medicine, Osaka-Sayama, Japan, JP aut NATIONALLICENCE 700 1- Kodaira S. Department of Surgery, Keio University School of Medicine, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Kato T. Department of Surgery, Aichi Cancer Center, Nagoya, Japan, JP aut NATIONALLICENCE 700 1- Kotake K. Department of Surgery, Tochigi Cancer Center, Utsunomiya, Japan, JP aut NATIONALLICENCE 700 1- Oka H. Department of Surgery, Showa University Fujigaoka Hospital, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Masuike T. Analytical Research Laboratory, Kyowa Hakko Kogyo Co. Ltd., Mishima, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer