caa a22 4500 477057608 CHVBK 20180405111351.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/s002280050080 doi (NATIONALLICENCE)springer-10.1007/s002280050080 Lack of a kinetic interaction between fluconazole and mexiletine [Elektronische Daten] [K. Ueno, R. Yamaguchi, K. Tanaka, M. Sakaguchi, Y. Morishima, K. Yamauchi, A. Iwai] Abstract.: Objective. To investigate the effect of fluconazole on the kinetics of mexiletine. Methods. Six healthy male volunteers participated in a crossover study. On the 1st day, the subjects received 200 mg mexiletine alone. On days 2-7 they received 200 mg fluconazole orally, and on day 8 they received 200 mg mexiletine and 200 mg fluconazole concomitantly. In a third phase two subjects received 400 mg fluconazole daily. Results. No differences in concentrations were observed between the three phases. The area under the concentration curves (AUC) after administration of mexiletine alone and in combination with fluconazole 200 mg/day were 6.63 and 7.31 μg ⋅ h ⋅ ml−1, respectively. Conclusion. These findings suggest that fluconazole does not inhibit mexiletine metabolism. Springer-Verlag Berlin Heidelberg, 1996 Key words Fluconazole nationallicence Mexiletine nationallicence CYP1A2 nationallicence drug interaction nationallicence metabolism nationallicence Ueno K. Department of Pharmacy, National Sengokuso Hospital, 1191 Nagose, Kaizuka-shi, Osaka, 597 Japan, JP aut Yamaguchi R. Department of Internal Medicine, National Sengokuso Hospital, 1191 Nagose, Kaizuka-shi, Osaka, 597 Japan, JP aut Tanaka K. Sirasagi Hospital, 11-23, 7-chome, Kumata, Higashisumiyoshi-ku, Osaka, 546 Japan, JP aut Sakaguchi M. Department of Anesthesiology, Kinki University School of Medicine, 337-2 Ohno-higashi, Osakasayama-shi, Osaka, 586 Japan, JP aut Morishima Y. Department of Laboratory, Kinki University Hospital, 337-2 Ohno-higashi, Osakasayama-shi, Osaka, 586 Japan, JP aut Yamauchi K. Department of Pharmacy, National Sabae Hospital, 2-31, 1-chome, Sanroku-cho, Sabae-shi, Fukui, 916 Japan, JP aut Iwai A. Department of Pharmacy, National Sabae Hospital, 2-31, 1-chome, Sanroku-cho, Sabae-shi, Fukui, 916 Japan, JP aut https://doi.org/10.1007/s002280050080 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050080 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ueno K. Department of Pharmacy, National Sengokuso Hospital, 1191 Nagose, Kaizuka-shi, Osaka, 597 Japan, JP aut NATIONALLICENCE 700 1- Yamaguchi R. Department of Internal Medicine, National Sengokuso Hospital, 1191 Nagose, Kaizuka-shi, Osaka, 597 Japan, JP aut NATIONALLICENCE 700 1- Tanaka K. Sirasagi Hospital, 11-23, 7-chome, Kumata, Higashisumiyoshi-ku, Osaka, 546 Japan, JP aut NATIONALLICENCE 700 1- Sakaguchi M. Department of Anesthesiology, Kinki University School of Medicine, 337-2 Ohno-higashi, Osakasayama-shi, Osaka, 586 Japan, JP aut NATIONALLICENCE 700 1- Morishima Y. Department of Laboratory, Kinki University Hospital, 337-2 Ohno-higashi, Osakasayama-shi, Osaka, 586 Japan, JP aut NATIONALLICENCE 700 1- Yamauchi K. Department of Pharmacy, National Sabae Hospital, 2-31, 1-chome, Sanroku-cho, Sabae-shi, Fukui, 916 Japan, JP aut NATIONALLICENCE 700 1- Iwai A. Department of Pharmacy, National Sabae Hospital, 2-31, 1-chome, Sanroku-cho, Sabae-shi, Fukui, 916 Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer