caa a22 4500 477057705 CHVBK 20180405111351.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/s002280050133 doi (NATIONALLICENCE)springer-10.1007/s002280050133 Effects of omeprazole and cimetidine on the urinary metabolic ratio of proguanil in healthy volunteers [Elektronische Daten] [A. A. Somogyi, H. A. Reinhard, F. Bochner] Objective: To examine the effects of omeprazole and cimetidine on the urinary recovery and metabolic ratio of proguanil in healthy subjects. Methods: A metabolic interaction study was conducted in 12 young, healthy extensive metabolisers of proguanil, a CYP2C19 substrate, following a single 100 mg oral dose by analysis of urine collected for 8 hours. Results: Concomitant administration of omeprazole (20 mg), a CYP2C19 substrate, had no significant effect on the urinary recovery of proguanil or cycloguanil, or the ratio of cycloguanil to proguanil [mean 0.76 (95% CI: 0.53 to 0.98) proguanil alone; mean 0.65 (95% CI: 0.40 to 0.89) proguanil plus omeprazole]. In contrast, cimetidine (400 mg), a general CYP inhibitor and renal organic cation secretion inhibitor, decreased the urinary recovery of cycloguanil and reduced the metabolic ratio from a mean of 0.76 to 0.54 (P < 0.01). In 3 poor metabolisers of proguanil, cimetidine had no effect on the proguanil metabolic ratio. Conclusion: The concomitant administration of omeprazole or cimetidine will not result in phenocopying extensive metabolisers of proguanil, although cimetidine inhibits the formation of cycloguanil in extensive metabolisers. Springer-Verlag Berlin Heidelberg, 1996 Key words Proguanil nationallicence Omeprazole nationallicence Cimetidine nationallicence druginteraction nationallicence metabolic ratio nationallicence CYP2C19 nationallicence Somogyi A. A. Department of Clinical and Experimental Pharmacology, University of Adelaide, 5005, Adelaide, Australia aut Reinhard H. A. Department of Clinical and Experimental Pharmacology, University of Adelaide, 5005, Adelaide, Australia aut Bochner F. Department of Clinical and Experimental Pharmacology, University of Adelaide, 5005, Adelaide, Australia aut https://doi.org/10.1007/s002280050133 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050133 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Somogyi A. A. Department of Clinical and Experimental Pharmacology, University of Adelaide, 5005, Adelaide, Australia aut NATIONALLICENCE 700 1- Reinhard H. A. Department of Clinical and Experimental Pharmacology, University of Adelaide, 5005, Adelaide, Australia aut NATIONALLICENCE 700 1- Bochner F. Department of Clinical and Experimental Pharmacology, University of Adelaide, 5005, Adelaide, Australia aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer