caa a22 4500 477057721 CHVBK 20180405111351.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/s002280050129 doi (NATIONALLICENCE)springer-10.1007/s002280050129 Codeine disposition in human hair after single and multiple doses [Elektronische Daten] [D. E. Rollins, D. G. Wilkins, G. G. Krueger] Objective: We studied the dose-proportion and time-course relationships for the incorporation of codeine into human hair after the administration of three different doses. Subjects: Male volunteers, with dark hair, were given oral codeine either as a single dose of 60 mg (n = 7) or 120 mg (n = 12), or as multiple doses of 30 mg 3 times daily for 5 days (n = 7) (450 mg total dose). Methods: Blood and urine were collected for various times for up to 72 h after dosing. Scalp hair was collected initially by plucking (up to 4 weeks) and later by cutting for up to 10 weeks. Plasma, urine, proximal 1 cm of hair and distal hair were each analyzed for codeine and its metabolites by positive-ion chemical ionization ion trap gas chromatography/mass spectrometry. Results: Codeine was detected in the proximal 1 cm of hair within 30 min of an oral 120-mg dose. Codeine was not detected in the distal hair segment until 3 weeks after receiving a dose of codeine. Codeine was detected in distal hair segments for at least 10 weeks at 30 pg mg−1 hair following a single 120 mg codeine dose and at 90 pg mg−1 hair following 30 mg codeine 3 times a day for 5 days. Morphine or the glucuronides of codeine or morphine were not detected in the hair specimens of these subjects. Conclusion: Codeine is rapidly distributed into the germanitive elements of hair in a dose-proportional manner. A portion of the codeine remains bound as the hair grows and can be detected in distal hair for up to 10 weeks after a single dose. Springer-Verlag Berlin Heidelberg, 1996 Keywords Codeine nationallicence Scalp hair nationallicence disposition nationallicence Rollins D. E. Center for Human Toxicology, Department of Pharmacology and Toxicology, Room 490, Biomedical Polymers Research Building, University of Utah Health Sciences Centre, 84H2, Utah, Salt Lake City, USA aut Wilkins D. G. Center for Human Toxicology, Department of Pharmacology and Toxicology, Room 490, Biomedical Polymers Research Building, University of Utah Health Sciences Centre, 84H2, Utah, Salt Lake City, USA aut Krueger G. G. Division of Dermatology, Department of Internal Medicine, University of Utah Health Sciences Center, Utah, Salt Lake City, USA aut https://doi.org/10.1007/s002280050129 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050129 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rollins D. E. Center for Human Toxicology, Department of Pharmacology and Toxicology, Room 490, Biomedical Polymers Research Building, University of Utah Health Sciences Centre, 84H2, Utah, Salt Lake City, USA aut NATIONALLICENCE 700 1- Wilkins D. G. Center for Human Toxicology, Department of Pharmacology and Toxicology, Room 490, Biomedical Polymers Research Building, University of Utah Health Sciences Centre, 84H2, Utah, Salt Lake City, USA aut NATIONALLICENCE 700 1- Krueger G. G. Division of Dermatology, Department of Internal Medicine, University of Utah Health Sciences Center, Utah, Salt Lake City, USA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer