caa a22 4500 477057810 CHVBK 20180405111351.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00195939 doi (NATIONALLICENCE)springer-10.1007/BF00195939 The anti-ulcer drug sucralfate does not affect gastric nicotine levels [Elektronische Daten] [G. Lindell, H. Graffner] Objective: It has been claimed that sucralfate can overcome the negative effects of nicotine in patients with peptic ulcer disease, although the possible mechanism being unknown. This study was performed in order to test whether sucralfate was capable of binding intragastric nicotine, thus making it impossible for the substance to exert effect. Method: Nicotine was administered via transdermal patches or as capsules yielding gastric concentrations of 40-2980 ng·ml−1. Gastric juice aspirates (n=9) were incubated with sucralfate, which was then separated by centrifugation, and the nicotine concentration was compared in incubated and non-incubated samples. Results: A median decrease of 13% (range 0-27%) in nicotine concentration was seen after incubation with sucralfate (P=0.01). Conclusion: The binding of nicotine to the precipitating agent sucralfate is not sufficient effectively to remove nicotine from the gastric juice. Springer-Verlag, 1996 Intragastric nicotine nationallicence Peptic ulcer nationallicence Sucralfate nationallicence smoking nationallicence Lindell G. Department of Surgery, Lund University Hospital, S-22185, Lund, Sweden aut Graffner H. Helsingborg Hospital, Helsingborg, Sweden aut European Journal of Clinical Pharmacology Springer-Verlag 49/6(1996-03-01), 511-513 0031-6970 49:6<511 1996 49 228 https://doi.org/10.1007/BF00195939 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00195939 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lindell G. Department of Surgery, Lund University Hospital, S-22185, Lund, Sweden aut NATIONALLICENCE 700 1- Graffner H. Helsingborg Hospital, Helsingborg, Sweden aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 49/6(1996-03-01), 511-513 0031-6970 49:6<511 1996 49 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer