caa a22 4500 477057837 CHVBK 20180405111351.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00195934 doi (NATIONALLICENCE)springer-10.1007/BF00195934 Pharmacokinetics of dexamethasone in premature neonates [Elektronische Daten] [R. Lugo, M. Nahata, J. Menke, E. McClead] Objective: Dexamethasone is frequently used in premature neonates with bronchopulmonary dysplasia, however little is known about its disposition in this population. Methods: We evaluated the pharmacokinetics of dexamethasone in 9 premature neonates with a mean gestational age of 27.3 weeks and a postnatal age of 21.8 days. Results: There was a strong relationship between clearance (4.96 ml·min−1·kg−1) and gestational age (r=0.884). Pharmacokinetic parameters were grouped based on a gestational age of less than 27 weeks (Group I) and greater than 27 weeks (Group II). Mean clearance in group I and group II was 1.69 and 7.57 ml·min−1·kg−1, respectively. Mean distribution volume in group I and II was 1.26 and 2.19 l·kg−1, respectively. No significant relationships were noted between the disposition of dexamethasone and ventilator requirements or adverse effects. Conclusion: The pharmacokinetics of dexamethasone in premature neonates was related to gestational age. Springer-Verlag, 1996 Dexamethasone nationallicence Premature neonates nationallicence pharmacokinetics nationallicence bronchopulmonary dysplasia nationallicence infant nationallicence newborn nationallicence Lugo R. The Wexner Institute for Pediatric Research, Children's Hospital, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 43210, Columbus, Ohio, USA aut Nahata M. The Wexner Institute for Pediatric Research, Children's Hospital, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 43210, Columbus, Ohio, USA aut Menke J. The Wexner Institute for Pediatric Research, Children's Hospital, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 43210, Columbus, Ohio, USA aut McClead E. The Wexner Institute for Pediatric Research, Children's Hospital, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 43210, Columbus, Ohio, USA aut European Journal of Clinical Pharmacology Springer-Verlag 49/6(1996-03-01), 477-483 0031-6970 49:6<477 1996 49 228 https://doi.org/10.1007/BF00195934 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00195934 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lugo R. The Wexner Institute for Pediatric Research, Children's Hospital, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 43210, Columbus, Ohio, USA aut NATIONALLICENCE 700 1- Nahata M. The Wexner Institute for Pediatric Research, Children's Hospital, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 43210, Columbus, Ohio, USA aut NATIONALLICENCE 700 1- Menke J. The Wexner Institute for Pediatric Research, Children's Hospital, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 43210, Columbus, Ohio, USA aut NATIONALLICENCE 700 1- McClead E. The Wexner Institute for Pediatric Research, Children's Hospital, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, 43210, Columbus, Ohio, USA aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 49/6(1996-03-01), 477-483 0031-6970 49:6<477 1996 49 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer