caa a22 4500 477057845 CHVBK 20180405111351.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00195937 doi (NATIONALLICENCE)springer-10.1007/BF00195937 Pharmacokinetics of quinine in patients with chronic renal failure [Elektronische Daten] [P. Rimchala, J. Karbwang, K. Sukontason, V. Banmairuroi, P. Molunto, K. Na-Bangchang] Methods: We investigated the pharmacokinetics of quinine (Qn) following administration of a single oral dose of 600 mg Qn sulphate in six male Thai patients with a moderate degree of chronic renal failure (CRF), and six male Thai subjects with normal renal function. Results: The drug was well tolerated in both groups of subjects; no major adverse reactions were observed. A marked alteration in the pharmacokinetics of Qn was found in patients with CRF compared to healthy subjects; there were six signifiicant changes in the pharmacokinetic parameters. Absorption was delayed, but increased in CRF (tmax 4.5 vs 1.6 h, Cmax 6.17 vs 3.45 μg·ml−1). Total clearance was significantly reduced 0.94 vs 2.84 ml·min−1·kg−1, whereas Vz/f remained unchanged (1.82 vs 2.78 1·kg−1). This resulted in the increased values of AUC and prolongation of the t1/2z and MRT in the patients (AUC 181.5 vs 61.8 μg·min−1·ml−1, t1/2z 26 vs 9.7 h, MRT 36.4 vs 11.3 h). Median concentrations of plasma unbound fraction of Qn collected at 4 h after drug administration in patients and healthy subjects were 7.3 vs 9.8%, respectively. Springer-Verlag, 1996 Quinine nationallicence Malaria nationallicence pharmacokinetics nationallicence chronic renal failure nationallicence Rimchala P. Department of Medicine, Prapokklao Hospital, Chantaburi Province, Thailand aut Karbwang J. Clinical Parmacology Unit, Department of Clinical Tropical Medicine, Faculty of Medicine, Mahidol University, 420/6 Rajvithi Road, 10400, Pyathai, Bangkol, Thailand aut Sukontason K. Clinical Parmacology Unit, Department of Clinical Tropical Medicine, Faculty of Medicine, Mahidol University, 420/6 Rajvithi Road, 10400, Pyathai, Bangkol, Thailand aut Banmairuroi V. Clinical Parmacology Unit, Department of Clinical Tropical Medicine, Faculty of Medicine, Mahidol University, 420/6 Rajvithi Road, 10400, Pyathai, Bangkol, Thailand aut Molunto P. Clinical Parmacology Unit, Department of Clinical Tropical Medicine, Faculty of Medicine, Mahidol University, 420/6 Rajvithi Road, 10400, Pyathai, Bangkol, Thailand aut Na-Bangchang K. Clinical Parmacology Unit, Department of Clinical Tropical Medicine, Faculty of Medicine, Mahidol University, 420/6 Rajvithi Road, 10400, Pyathai, Bangkol, Thailand aut European Journal of Clinical Pharmacology Springer-Verlag 49/6(1996-03-01), 497-501 0031-6970 49:6<497 1996 49 228 https://doi.org/10.1007/BF00195937 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00195937 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rimchala P. Department of Medicine, Prapokklao Hospital, Chantaburi Province, Thailand aut NATIONALLICENCE 700 1- Karbwang J. Clinical Parmacology Unit, Department of Clinical Tropical Medicine, Faculty of Medicine, Mahidol University, 420/6 Rajvithi Road, 10400, Pyathai, Bangkol, Thailand aut NATIONALLICENCE 700 1- Sukontason K. Clinical Parmacology Unit, Department of Clinical Tropical Medicine, Faculty of Medicine, Mahidol University, 420/6 Rajvithi Road, 10400, Pyathai, Bangkol, Thailand aut NATIONALLICENCE 700 1- Banmairuroi V. Clinical Parmacology Unit, Department of Clinical Tropical Medicine, Faculty of Medicine, Mahidol University, 420/6 Rajvithi Road, 10400, Pyathai, Bangkol, Thailand aut NATIONALLICENCE 700 1- Molunto P. Clinical Parmacology Unit, Department of Clinical Tropical Medicine, Faculty of Medicine, Mahidol University, 420/6 Rajvithi Road, 10400, Pyathai, Bangkol, Thailand aut NATIONALLICENCE 700 1- Na-Bangchang K. Clinical Parmacology Unit, Department of Clinical Tropical Medicine, Faculty of Medicine, Mahidol University, 420/6 Rajvithi Road, 10400, Pyathai, Bangkol, Thailand aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 49/6(1996-03-01), 497-501 0031-6970 49:6<497 1996 49 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer