caa a22 4500 477058051 CHVBK 20180405111352.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF00226325 doi (NATIONALLICENCE)springer-10.1007/BF00226325 Increased risk of ischaemic heart disease mortality in elderly men using anxiolytics-hypnotics and analgesics [Elektronische Daten] Results of the 10-year follow-up of the prospective population study "Men born in 1914”, Malmö, Sweden [J. Merlo, B. Hedblad, M. Ögren, J. Ranstam, P. Östergren, A. Ekedahl, B. Hanson, S. Isacsson, H. Liedholm, A. Melander] Objectives: An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (IHD) mortality. Methods: Multivariate 10-year survival analysis in a population based cohort of 500 men born in 1914. Relative risks (RR) were adjusted by relevant confounders (blood pressure, serum cholesterol, diabetes mellitus, smoking habit, high alcohol consumption, history of previous IHD, cancer, and other diseases). Results: The RR of both all-cause and IHD mortality were significantly increased among those using both AHD and analgesics compared to those who took neither of these drugs: RR=1.8 for all-cause mortality, and RR=2.7 for IHD mortality. Conclusion: Although the number of cases was small, warranting interpretative caution, the current study suggests that the combined use of AHD (mainly benzodiazepines) and analgesics seems to be associated with an increase in all-cause and IHD mortality in elderly men. Springer-Verlag, 1996 Cardiovascular mortality nationallicence Anxiolyticshypnotics nationallicence pharmacoepidemiology nationallicence adverse drug effect nationallicence cohort study nationallicence benzodiazepines nationallicence analgesics nationallicence Merlo J. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut Hedblad B. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut Ögren M. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut Ranstam J. The NEPI Foundation, Malmö and Stockholm, Sweden aut Östergren P. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut Ekedahl A. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut Hanson B. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut Isacsson S. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut Liedholm H. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut Melander A. The NEPI Foundation, Malmö and Stockholm, Sweden aut European Journal of Clinical Pharmacology Springer-Verlag 49/4(1996-01-01), 261-265 0031-6970 49:4<261 1996 49 228 https://doi.org/10.1007/BF00226325 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00226325 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Merlo J. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut NATIONALLICENCE 700 1- Hedblad B. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut NATIONALLICENCE 700 1- Ögren M. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut NATIONALLICENCE 700 1- Ranstam J. The NEPI Foundation, Malmö and Stockholm, Sweden aut NATIONALLICENCE 700 1- Östergren P. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut NATIONALLICENCE 700 1- Ekedahl A. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut NATIONALLICENCE 700 1- Hanson B. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut NATIONALLICENCE 700 1- Isacsson S. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut NATIONALLICENCE 700 1- Liedholm H. Departments of Community Medicine, Lund University, Malmö University Hospital, S-20502, Malmö, Sweden aut NATIONALLICENCE 700 1- Melander A. The NEPI Foundation, Malmö and Stockholm, Sweden aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 49/4(1996-01-01), 261-265 0031-6970 49:4<261 1996 49 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer