caa a22 4500 477058140 CHVBK 20180405111352.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF00203774 doi (NATIONALLICENCE)springer-10.1007/BF00203774 Effect of β2-adrenoceptor agonists on plasma potassium and cardiopulmonary responses on exercise in patients with chronic obstructive pulmonary disease [Elektronische Daten] [C. Yang, H. Lin, M. Lin, C. Wang, C. Lee, H. Kuo] Objective: The effect of β2-adrenoceptor agonist-induced hypokalaemia on cardiac arrhythmias might be exacerbated during exercise, especially in patients with more compromised airway function. Methods: To evaluate the effect of β2-adrenoceptor agonists on plasma potassium and cardiopulmonary function during exercise, two identical submaximal treadmill exercise tests were performed, at least 48 h apart, by 13 patients with moderate to severe COPD (11 men and 2 women, mean age 66 y, mean FEV1/FVC ratio 48.9 (2.8)%) 30 min after they had received nebulised fenoterol or salbutamol (2 mg). The experiment was done as a randomised, double-blind, crossover trial after an initial baseline study with vehicle (0.45% saline). Plasma potassium concentration, spirometry and the degree of breathlessness (Borg scale) were measured before treatment and immediately after exercise; oxygen saturation, QTc interval and cardiac rhythm were monitored continuously before, during and for 30 min after exercise. Results: After the saline control, exercise caused an increase in Borg rating (of 4.9), a premature ventricular contractions (VPC) (2.8 beats/min), and a fall in oxygen saturation (-6.7%), but no significant change in plasma potassium (+0.04 mEq·dl−1), FEV1 or QTc interval. Inhalation of fenoterol and salbutamol did not affect QTc interval, Borg scale or VPC frequency at rest, but significantly increased the duration of exercise undertaken to reach the submaximal levels (786 s, versus 783 s) compared to the vehicle control. Following exercise, plasma potassium fell after fenoterol by 0.2 mEq·dl−1 and it increased after salbutamol by 0.1 mEq·dl−1 compared to baseline levels. Plasma potassium after exercise was significantly lower after fenoterol (3.2 mEq·dl−1) compared to the saline control (3.7 mEq · dl−1) and salbutamol (3.6 mEq · dl−1). Neither fenoterol nor salbutamol had any significant effect on the change in FEV1, oxygen saturation, Borg scale, frequency of VPCs or QTc interval during or after exercise compared to the saline control. Conclusion: When compared to salbutamol 2 mg, fenoterol 2 mg caused more marked hypokalaemia but no significant difference in cardiopulmonary response in patients with COPD during exercise. Springer-Verlag, 1996 Hypokalaemia nationallicence Fenoterol nationallicence Salbutamol nationallicence exercise nationallicence Yang C. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut Lin H. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut Lin M. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut Wang C. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut Lee C. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut Kuo H. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 341-345 0031-6970 49:5<341 1996 49 228 https://doi.org/10.1007/BF00203774 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00203774 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang C. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lin H. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lin M. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Wang C. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lee C. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Kuo H. Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 341-345 0031-6970 49:5<341 1996 49 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer