caa a22 4500 477058175 CHVBK 20180405111352.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF00203782 doi (NATIONALLICENCE)springer-10.1007/BF00203782 Effect of dose size on the pharmacokinetics of orally administered quinine [Elektronische Daten] [A. Sowunmi, A. Sowunmi, L. Salako] Plasma concentrations of quinine were measured by high-performance liquid chromatography (HPLC) after oral administration of 250, 500 and 1000 mg base to seven healthy adults. The doses were administered after an overnight fast. A washout period of at least 21 days was allowed between the doses. Area under the plasma concentration-time curve (AUC) for quinine increased in approximate proportion to the dose from 250 to 1000 mg. There was also a linear relationship between dose and maximum plasma concentration and dose and AUC in individual subjects. Time to reach peak plasma concentration remained unchanged over the dose range. There was no significant difference in elimination half-life, volume of distribution and systemic clearance over the dose range. The occurrence of adverse effects was dose and plasma quinine concentration dependent; central nervous system side effects increased as dose and plasma concentrations increased. These data suggest that after oral administration of quinine, linear pharmacokinetics occur in the dose range of 250-1000 mg. Springer-Verlag, 1996 Quinine nationallicence antimalarial pharmacokinetics nationallicence adverse effects nationallicence Sowunmi A. Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria aut Sowunmi A. Clinical Pharmacology Unit, University College Hospital, Ibadan, Nigeria aut Salako L. Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria aut European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 383-386 0031-6970 49:5<383 1996 49 228 https://doi.org/10.1007/BF00203782 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00203782 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sowunmi A. Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria aut NATIONALLICENCE 700 1- Sowunmi A. Clinical Pharmacology Unit, University College Hospital, Ibadan, Nigeria aut NATIONALLICENCE 700 1- Salako L. Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 383-386 0031-6970 49:5<383 1996 49 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer