caa a22 4500 477058183 CHVBK 20180405111352.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF00203785 doi (NATIONALLICENCE)springer-10.1007/BF00203785 Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease [Elektronische Daten] [K. Grønbaek, H. Friis, M. Feldman, J. Sonne, P. Andreasen] Methods: The effect of zinc supplementation on antipyrine clearance was evaluated in 14 outpatients with stable alcoholic liver disease, of whom nine had biopsy proven alcoholic cirrhosis. Results: There was no change in antipyrine clearance after 14 days of zinc supplementation (median 12.5 vs 12.9 ml · min−1). However, a significant increase in P-prothrombin-proconvertin was found. There was a positive correlation between S-zinc and antipyrine clearance at inclusion (rs=0.76) as well as after zinc supplementation (rs=0.72). Conclusion: No effect of zinc supplementation on antipyrine clearance was found. The positive correlation between S-zinc and antipyrine clearance could be due to the confounding effect of alcoholic liver disease. Springer-Verlag, 1996 Zinc supplementation nationallicence Antipyrine clearance nationallicence Liver cirrhosis nationallicence alcoholic liver disease nationallicence Grønbaek K. Department of Clinical Chemistry, University of Copenhagen, Gentofte Hospital, Niels Andersensvej 65, DK-2900, Hellerup, Denmark aut Friis H. Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark aut Feldman M. Medical Department F, University of Copenhagen, Gentofte Hospital, Gentofte, Denmark aut Sonne J. Medical Department F, University of Copenhagen, Gentofte Hospital, Gentofte, Denmark aut Andreasen P. Medical Department F, University of Copenhagen, Gentofte Hospital, Gentofte, Denmark aut European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 397-399 0031-6970 49:5<397 1996 49 228 https://doi.org/10.1007/BF00203785 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00203785 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grønbaek K. Department of Clinical Chemistry, University of Copenhagen, Gentofte Hospital, Niels Andersensvej 65, DK-2900, Hellerup, Denmark aut NATIONALLICENCE 700 1- Friis H. Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark aut NATIONALLICENCE 700 1- Feldman M. Medical Department F, University of Copenhagen, Gentofte Hospital, Gentofte, Denmark aut NATIONALLICENCE 700 1- Sonne J. Medical Department F, University of Copenhagen, Gentofte Hospital, Gentofte, Denmark aut NATIONALLICENCE 700 1- Andreasen P. Medical Department F, University of Copenhagen, Gentofte Hospital, Gentofte, Denmark aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 397-399 0031-6970 49:5<397 1996 49 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer