caa a22 4500 477058221 CHVBK 20180405111352.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF00203789 doi (NATIONALLICENCE)springer-10.1007/BF00203789 Pharmacokinetic interaction between diltiazem and nortriptyline [Elektronische Daten] [S. Krähenbühl, V. Smith-Gamble, C. Hoppel] Objective: Case report of a pharmacokinetic interaction between diltiazem and nortriptyline. Methods: Determination of plasma nortriptyline concentrations by HPLC. Calculation of nortriptyline clearances and half-life by formulae used routinely in therapeutic drug monitoring. Results: The average plasma concentration of nortriptyline at steady state (Css) divided by the amount of nortriptyline administered per time rose significantly in a patient with concomitant administration of diltiazem, suggesting increased bioavailability and/or decreased clearance of nortriptyline. Conclusions: There is a significant pharmacokinetic interaction between diltiazem and nortriptyline, which is probably due to a reduction in the first pass clearance of nortriptyline, leading to an increase in its bioavailability. Interactions with tricyclic antidepressants may be clinically important owing to the narrow therapeutic range and potential toxicity of these drugs. We have observed an interaction between diltiazem and nortriptyline, leading to increased plasma nortriptyline concentrations. Springer-Verlag, 1996 Krähenbühl S. Departments of Pharmacology and Medicine, Division of Psychiatry, VA Medical Center, Case Western Reserve University School of Medicine, Cleveland, USA aut Smith-Gamble V. Departments of Pharmacology and Medicine, Division of Psychiatry, VA Medical Center, Case Western Reserve University School of Medicine, Cleveland, USA aut Hoppel C. Division of Clinical Pharmacology, VA Medical Center, Case Western Reserve University School of Medicine, Cleveland, USA aut European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 417-419 0031-6970 49:5<417 1996 49 228 https://doi.org/10.1007/BF00203789 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00203789 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Krähenbühl S. Departments of Pharmacology and Medicine, Division of Psychiatry, VA Medical Center, Case Western Reserve University School of Medicine, Cleveland, USA aut NATIONALLICENCE 700 1- Smith-Gamble V. Departments of Pharmacology and Medicine, Division of Psychiatry, VA Medical Center, Case Western Reserve University School of Medicine, Cleveland, USA aut NATIONALLICENCE 700 1- Hoppel C. Division of Clinical Pharmacology, VA Medical Center, Case Western Reserve University School of Medicine, Cleveland, USA aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 417-419 0031-6970 49:5<417 1996 49 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer