caa a22 4500 47705823X CHVBK 20180405111352.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF00203788 doi (NATIONALLICENCE)springer-10.1007/BF00203788 Pharmacokinetics of moxisylyte in healthy volunteers after intracavernous injection of increasing doses [Elektronische Daten] [F. Bressolle, P. Costa, R. Rouzier-Panis, C. Marquer] Objective: The concentration-time profiles of specific metabolites of moxisylyte, an α-adrenoceptor blocking agent, in the plasma and urine from 18 healthy volunteers were investigated after intracavernous (IC) administrations at three dose levels (10, 20 and 30 mg). Results: Four metabolites, unconjugated desacetyl-moxisylyte (DAM), DAM glucuronide, and DAM and monodesmethylated DAM (MDAM) sulphates were found in plasma and urine. For all metabolites, t1/2 elimination was independent of the administered dose (1.19 h for unconjugated DAM; 1.51 h for DAM glucuronide; 1.51 h for DAM sulphate; and 2.17 h for MDAM sulphate). Cmax and AUC increased in direct proportion to dose, except for the inactive DAM glucuronide. Any the differences detected were small and equivalence of the three doses can be accepted. Conclusion: The pharmacokinetics of moxisylyte in humans following intracavernous administration were linear in the dose range 10 to 30 mg. Springer-Verlag, 1996 Moxisylyte nationallicence pharmacokinetics nationallicence intracavernous administration nationallicence healthy volunteers nationallicence adverse events nationallicence metabolism nationallicence Bressolle F. Laboratoire de Pharmacocinétique, Faculté de Pharmacie, Université de Montpellier I, 15 Avenue Ch. Flahault, F-34060, Montpellier Cedex 01, France aut Costa P. Service d'Urologie-Andrologie, Hôpital G. Doumergue, Nîmes, France aut Rouzier-Panis R. Centre CAP, Hôpital G. Doumergue, Nîmes, France aut Marquer C. Service de Pharmacocinétique, Laboratoires Debat, Garches, France aut European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 411-415 0031-6970 49:5<411 1996 49 228 https://doi.org/10.1007/BF00203788 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00203788 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bressolle F. Laboratoire de Pharmacocinétique, Faculté de Pharmacie, Université de Montpellier I, 15 Avenue Ch. Flahault, F-34060, Montpellier Cedex 01, France aut NATIONALLICENCE 700 1- Costa P. Service d'Urologie-Andrologie, Hôpital G. Doumergue, Nîmes, France aut NATIONALLICENCE 700 1- Rouzier-Panis R. Centre CAP, Hôpital G. Doumergue, Nîmes, France aut NATIONALLICENCE 700 1- Marquer C. Service de Pharmacocinétique, Laboratoires Debat, Garches, France aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 411-415 0031-6970 49:5<411 1996 49 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer