caa a22 4500 477058256 CHVBK 20180405111352.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF00203781 doi (NATIONALLICENCE)springer-10.1007/BF00203781 Analgesic effects of propyphenazone in comparison to its combination with caffeine [Elektronische Daten] [H. Kraetsch, T. Hummel, J. Lötsch, R. Kussat, G. Kobal] Objective: The aim of the study was to investigate whether the analgesic effect of propyphenazone (PROP) was increased when it was administered in combination with caffeine (CAFF). Methods: For assessment of analgesia a model was chosen based on chemo-somatosensory event-related potentials (CSSERP) elicited by stimulation of the nasal mucosa. Twenty healthy volunteers participated in the experiments. The study followed a placebo-controlled, randomised, double-blind, 5-fold cross-over design. Each of the 5 medications (400 mg PROP, 600 mg PROP, 400 mg PROP+100 mg CAFF, 600 mg PROP+150 mg CAFF, placebo) was orally administered. Experiments were separated by at least 5 days. In addition to assessment of CSSERP, subjects estimated the intensity of the stimulus. Drug effects unrelated to nociception were monitored, and in addition, the plasma levels of PROP were also analysed. Results: While 400 mg PROP did not significantly reduce the amplitude of CSSERP in comparison to placebo, all other medications produced a significant decrease in amplitudes. For both dosages of PROP, there was a significant amplification of the antinociceptive effect of PROP by CAFF, as indicated by the decrease in CSSERP amplitude. A significant effect of the factor "drug” was also found in the spontaneous EEG, indicating an arousal reaction after CAFF. No significant differences between plasma levels of PROP were found when applied either alone or in combination with CAFF. Conclusion: The significant increase in the antinociceptive effect of PROP when administered together with caffeine appears to be related either to amplification of PROP's antinociceptive actions by CAFF or an atinociceptive effect of CAFF itself. Springer-Verlag, 1996 Phasic pain nationallicence Carbon dioxide nationallicence irritation nationallicence chemical stimulation nationallicence chemo-somatosensory event-related potential nationallicence analgesia nationallicence caffeine nationallicence Kraetsch H. Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-91054, Erlangen, Germany aut Hummel T. Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-91054, Erlangen, Germany aut Lötsch J. Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-91054, Erlangen, Germany aut Kussat R. Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-91054, Erlangen, Germany aut Kobal G. Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-91054, Erlangen, Germany aut European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 377-382 0031-6970 49:5<377 1996 49 228 https://doi.org/10.1007/BF00203781 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00203781 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kraetsch H. Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Hummel T. Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Lötsch J. Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Kussat R. Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-91054, Erlangen, Germany aut NATIONALLICENCE 700 1- Kobal G. Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-91054, Erlangen, Germany aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 49/5(1996-02-01), 377-382 0031-6970 49:5<377 1996 49 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer