caa a22 4500 477061575 CHVBK 20180405111402.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF01061915 doi (NATIONALLICENCE)springer-10.1007/BF01061915 Wittkowsky Ann University of Washington School of Pharmacy, Seattle, Washington aut Workshop: Warfarin drug interactions: Detection, prediction, prevention [Elektronische Daten] [Ann Wittkowsky] Oral anticoagulant therapy is frequently complicated by the interaction of warfarin with numerous drug compounds. While concurrent use of warfarin and interacting drugs is not an absolute contraindication, clinicians must employ various strategies to detect possible drug interactions, predict patient response, and prevent adverse clinical outcomes. Thorough ongoing patient education plays a significant role in the prevention of unreported medication use. Patient interviewing techniques must include an assessment of nonprescription drug use as well as drugs taken by prescription. Recent developments in the characterization of the stereoselective, regioselective oxidative metabolism of warfarin may help to explain the unpredictable nature of warfarin drug interactions with respect to patient susceptibility, magnitude of response, time of onset, and duration of effect. When an interacting drug is initiated, discontinued, or used intermittently, adverse clinical outcomes can be avoided by diligent monitoring of prothrombin time, routine physical assessment of patient response, and appropriate warfarin dosage alterations. Kluwer Academic Publishers, 1996 warfarin nationallicence drug interaction nationallicence thromboembolism nationallicence stereochemistry nationallicence Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 2/4(1996-03-01), 295-299 0929-5305 2:4<295 1996 2 11239 https://doi.org/10.1007/BF01061915 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01061915 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Wittkowsky Ann University of Washington School of Pharmacy, Seattle, Washington aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 2/4(1996-03-01), 295-299 0929-5305 2:4<295 1996 2 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer