caa a22 4500 477061702 CHVBK 20180405111402.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00226414 doi (NATIONALLICENCE)springer-10.1007/BF00226414 Renal vein thrombosis and selective arterial or venous thrombolytic therapy [Elektronische Daten] [Zhao-Long Wu, Kang-Rong Zhou, Lu-tan Liao] Summary : Background: Renal vein thrombosis (RVT) complicating the nephrotic syndrome is associated with a poor prognosis. Methods/Results: RVT was diagnosed in 12 of 60 patients with a diagnosis of nephrotic syndrome suggested by computed tomography (CT) and subsequently confirmed by selective renal angiography. Fifty patients carried a diagnosis of primary glomerulonephritis with various pathological findings, and 10 patients had lupus nephritis. Renal vein and peripheral vein blood samples were collected in the 12 patients with RVT and were assayed for fibrin(ogen) degradation products (FDP), antithrombin III (AT III), VIIIR:AG, and fibrinogen. The results suggested a state of hypercoagulation. Of these 12 patients, 7 were given 200,000 units of urokinase (UK) over 60 minutes in divided doses selectively via the renal vein. Five patients were given 200,000 units UK selectively into the renal artery. All patients also received 2.5 mg/day warfarin and 75 mg/day persantine. Except for three patients with focal glomerulosclerosis, all patients received 40 mg/day prednisone. After 1 month, the CT scan and blood samples for FDP, AT III, VIIIR:AG, and fibrinogen were repeated. Patients receiving intra-arterial UK had complete resolution of their thrombi. Complete resolution was also suggested in 2 of the 7 patients receiving UK by renal vein, and there was partial resolution in the other five. The hypercoagulation state decreased in all patients. Conclusions: We conclude that RVT is not an uncommon event in patients with nephrotic syndrome. The diagnosis can be supported reliably using abdominal CT scanning. Although a small number of patients were included in this nonrandomized study, it appeared that intra-arterial thrombolytic therapy yielded better results. The patients with minimal change disease have a good prognosis. Kluwer Academic Publishers, 1996 renal vein thrombosis nationallicence thrombolysis nationallicence urokinase nationallicence Wu Zhao-Long Zhong Shan Hospital, Shanghai Medical University, Shanghai, China aut Zhou Kang-Rong Zhong Shan Hospital, Shanghai Medical University, Shanghai, China aut Liao Lu-tan Zhong Shan Hospital, Shanghai Medical University, Shanghai, China aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/1(1996-03-01), 67-70 0929-5305 3:1<67 1996 3 11239 https://doi.org/10.1007/BF00226414 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00226414 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu Zhao-Long Zhong Shan Hospital, Shanghai Medical University, Shanghai, China aut NATIONALLICENCE 700 1- Zhou Kang-Rong Zhong Shan Hospital, Shanghai Medical University, Shanghai, China aut NATIONALLICENCE 700 1- Liao Lu-tan Zhong Shan Hospital, Shanghai Medical University, Shanghai, China aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/1(1996-03-01), 67-70 0929-5305 3:1<67 1996 3 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer