caa a22 4500 477061729 CHVBK 20180405111402.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00226404 doi (NATIONALLICENCE)springer-10.1007/BF00226404 Influence of contraceptive pill use, premenopause and postmenopausal state on hemostatic parameters in ethnic Chinese women [Elektronische Daten] [Paul Chan, Chih Jung Yeh, Wen Harn Pan] Abstract.: Background: Epidemiological studies has shown that increased fibrinogen and factor VIIc are two independent risk factors for cardiovascular disease (CVD). Post-menopausal women have a higher incidence of CVD than premenopausal women; one possible explanation is the increase of fibrinogen. Purpose: This study was undertaken to evaluate the influence of oral contraceptive pill use and post-menopausal status on coagulation factors in ethnic Chinese women. Patients and methods: This study included 1402 women aged 40-55 years, with 288 premenopausal women taking oral contraceptives and 364 postmenopausal women. All subjects underwent blood examination of prothrombin time, activated partial thromboplastin time, fibrinogen, factor VIIc, factor VIIIc, plasminogen, and antithrombin III. Results: Data show that oral contraceptives users had a significant increase in plasminogen (91.7 ± 40.7 vs. 80.0 ± 26.5%; p < 0.01), while the levels of other hemostatic parameters were similar to non-contraceptive pill users. Postmenopausal women also had higher levels of plasminogen (113 ± 36.2 vs. 108.7 ± 30.7%; p = 0.06); the other parameters also show no statistical significance. Conclusions: Contrary to previous reports, which show elevation of fibrinogen and antithrombin III in menopause and in pill users, this study shows that only plasminogen levels exhibit a statistically significant contraceptive trend in Chinese women. Whether racial difference may account for the discrepancy in the present results needs further evaluation. Kluwer Academic Publishers, 1996 hemostatic parameters nationallicence contraceptive pill nationallicence premenopause nationallicence postmenopause nationallicence women nationallicence Chan Paul Department of Medicine, Taipei Municipal Chung-Hsiao Hospital, Institute of Clinical Medicine of National Yang-Ming University, Taipei, Taiwan aut Jung Yeh Chih Department of Medicine, Taipei Municipal Chung-Hsiao Hospital, Institute of Clinical Medicine of National Yang-Ming University, Taipei, Taiwan aut Harn Pan Wen Department of Medicine, Taipei Municipal Chung-Hsiao Hospital, Institute of Clinical Medicine of National Yang-Ming University, Taipei, Taiwan aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/1(1996-03-01), 9-12 0929-5305 3:1<9 1996 3 11239 https://doi.org/10.1007/BF00226404 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00226404 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chan Paul Department of Medicine, Taipei Municipal Chung-Hsiao Hospital, Institute of Clinical Medicine of National Yang-Ming University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Jung Yeh Chih Department of Medicine, Taipei Municipal Chung-Hsiao Hospital, Institute of Clinical Medicine of National Yang-Ming University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Harn Pan Wen Department of Medicine, Taipei Municipal Chung-Hsiao Hospital, Institute of Clinical Medicine of National Yang-Ming University, Taipei, Taiwan aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/1(1996-03-01), 9-12 0929-5305 3:1<9 1996 3 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer